145915-72-6Relevant academic research and scientific papers
Structure-based design of isoindoline-1,3-diones and 2,3- dihydrophthalazine-1,4-diones as novel B-Raf inhibitors
Wang, Xiaolun,Salaski, Edward J.,Berger, Dan M.,Powell, Dennis,Hu, Yongbo,Wojciechowicz, Donald,Collins, Karen,Frommer, Eileen
, p. 6941 - 6944 (2012/01/06)
Structure-guided design led to the discovery of novel chemical scaffolds for B-Raf inhibitors. Both type I and type II kinase inhibitors have been explored and lead compounds with good potency and excellent selectivity have been identified.
