1459246-71-9Relevant articles and documents
Synthesis of the tolerance-inducing oligosaccharide lacto-N-fucopentaose III bearing an activated linker
Zhang, Junfeng,Zou, Lu,Lowary, Todd L.
, p. 156 - 163 (2014/03/21)
A concise synthetic route to an immunomodulatory pentasaccharide, lacto-N-fucopentaose III (1) and its corresponding human serum albumin conjugate, is described. Key transformations of the strategy include two highly regio- and stereoselective glycosylations for the construction of disaccharide 10 and pentasaccharide 12, a Birch reduction for deprotection of benzyl ethers, and a UV-promoted radical addition of a thiol to an alkene for modification of the aglycone.