1459258-87-7Relevant academic research and scientific papers
Scalable Rhodium(III)-Catalyzed Aryl C?H Phosphorylation Enabled by Anodic Oxidation Induced Reductive Elimination
Wu, Zheng-Jian,Su, Feng,Lin, Weidong,Song, Jinshuai,Wen, Ting-Bin,Zhang, Hui-Jun,Xu, Hai-Chao
supporting information, p. 16770 - 16774 (2019/11/03)
Transition metal catalyzed C?H phosphorylation remains an unsolved challenge. Reported methods are generally limited in scope and require stoichiometric silver salts as oxidants. Reported here is an electrochemically driven RhIII-catalyzed aryl C?H phosphorylation reaction that proceeds through H2 evolution, obviating the need for stoichiometric metal oxidants. The method is compatible with a variety of aryl C?H and P?H coupling partners and particularly useful for synthesizing triarylphosphine oxides from diarylphosphine oxides, which are often difficult coupling partners for transition metal catalyzed C?H phosphorylation reactions. Experimental results suggest that the mechanism responsible for the C?P bond formation involves an oxidation-induced reductive elimination process.
Rhodium-Catalyzed Direct C-H Phosphorylation of (Hetero)arenes Suitable for Late-Stage Functionalization
Min, Minsik,Kang, Dahye,Jung, Sungwoo,Hong, Sungwoo
supporting information, p. 1296 - 1301 (2016/04/26)
Efficient rhodium-catalyzed direct C-H phosphorylation of (hetero)arenes was developed. Various directing groups and a wide range of substrates, including heterocycles, can be utilized in this C-H phosphorylation process, allowing for the rapid installation of the phosphonate group into medicinally and biologically important privileged scaffolds. The efficient and straightforward method could serve as a new tool to streamline late-stage C-H functionalization for preparing aryl phosphonates, which are important structural motif in synthetic and medicinal chemistry.
Pyridine-directed palladium-catalyzed phosphonation of C(sp2)-H bonds
Li, Changkun,Yano, Takaaki,Ishida, Naoki,Murakami, Masahiro
supporting information, p. 9801 - 9804 (2013/09/23)
Follow the guide: The palladium-catalyzed phosphonation of a C(sp 2)-H bond occurs through the use of a pyridyl group as the directing group. α-Hydroxyalkylphosphonate is used as the phosphonating reagent (see scheme). Copyright
