145926-28-9

Basic information

• Product Name: (R)-(+)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHALENECHLORO(P-CYMENE)RUTHENIUM CHLORIDE
• Synonyms: [(S)-2,2'-BIS-(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL]-CHLORO-(P-CYMENE)-RUTHENIUMCHLORIDE;(S)-(-)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHALENECHLORO(P-CYMENE)RUTHENIUM CHLORIDE;(R)-(+)-2,2'-[BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL]CHLORO(P-CYMENE)RUTHENIUM;[(R)-2,2'-BIS-(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL]-CHLORO-(P-CYMENE)-RUTHENIUMCHLORIDE;(R)-(+)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHALENECHLORO(P-CYMENE)RUTHENIUM CHLORIDE;CHLORO[(R)-(+)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM (II) CHLORIDE;CHLORO[(S)-(-)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHYL](P-CYMENE)RUTHENIUM (II) CHLORIDE;(R)-RuCl[(p-cymene)(BINAP)]Cl
• CAS NO: 145926-28-9
• Molecular Formula: C₅₄H₄₆ClP₂Ru*Cl
• Molecular Weight: 928.87
• EINECS: 1592732-453-0
• Product Categories: Ru
• Mol File: 145926-28-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: >100°C
• Boiling Point: 724.3°Cat760mmHg
• Flash Point: 419°C
• Appearance: orange/Powder
• Density: g/cm³
• Storage Temp.: Freezer (-20°C)
• Water Solubility: Insoluble in water
• Sensitive: Air Sensitive
• CAS DataBase Reference: (R)-(+)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHALENECHLORO(P-CYMENE)RUTHENIUM CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHALENECHLORO(P-CYMENE)RUTHENIUM CHLORIDE(145926-28-9)
• EPA Substance Registry System: (R)-(+)-2,2'-BIS(DIPHENYLPHOSPHINO)-1,1'-BINAPHTHALENECHLORO(P-CYMENE)RUTHENIUM CHLORIDE(145926-28-9)

Safety Data

• Hazard Codes: Xn
• Statements: 68/20/21/22-36/37/38-20/21/22
• Safety Statements: 45-36/37/39-26
• WGK Germany: 3
• Hazardous Substances Data: 145926-28-9(Hazardous Substances Data)

Usage

Reactions

An efficient catalytic asymmetric synthesis of a β2-amino acid on a multikilogram scale.

Chemical Properties

Brown crystallaline powder

Uses

Different sources of media describe the Uses of 145926-28-9 differently. You can refer to the following data:
1. (R)-RuCl[(p-cymene)(BINAP)]Cl is a ruthenium BINAP catalysts.
2. Takasago Ligands and Complexes for Asymmetric Reactions

Upstream product

• 52462-29-0 [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ 
• 76144-87-1 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl 
• 76144-87-1 (S)-(1,1'-binaphthalene)-2,2'-diylbis(diphenylphosphine) 

Relevant articles and documents

The Total Synthesis of Epothilone D as a Yardstick for Probing New Methodologies

Here, a concise and highly convergent synthesis of epothilone D was investigated, relying on fragments of equal complexity that could be prepared in gram scale quantities. The strategy to construct the fragments includes the use of a previously reported enantiospecific zinc-catalyzed cross-coupling of an α-hydroxy ester triflate with a Grignard reagent, the application of a hydroboration/boron–magnesium exchange sequence for the rapid construction of the Z-substituted trisubstituted double bond present in the natural product, and a Noyori-type hydrogenation to install the β-hydroxy ester moiety of the southern part. The key to success is the diastereoselective head-to-tail macrolactonization by an intramolecular addition of the corresponding ω-alkynyl-substituted carboxylic acids to construct a new stereocenter in the macrocyclic core structure in one single step.

On the mechanism of an asymmetric α,β-unsaturated carboxylic acid hydrogenation: Application to the synthesis of a PGD2 receptor antagonist

Ruthenium complexes employing axially chiral ligands were found to be effective asymmetric hydrogenation catalysts for the reduction of α,β-unsaturated ene acid 1-E to give 2, a prostaglandin D2 (PGD2) receptor antagonist. With [(S-B

Synthesis of New Cationic BINAP-Ruthenium(II) Complexes and their Use in Asymmetric Hydrogenation

Reaction of 2 (1) and (S)-BINAP gives cationic BINAP-ruthenium complexes of the formula Y (2) (X = Cl, Br, and I; Y = Cl, Br, I, BF4, and BPh4; arene = C6H6 and p-MeC6H4CHMe2) which are efficient catalyst precursors for enantioselective hydrogenation of various prochiral alkenic and ketonic substrates ; a crystal structure of (2) (with X = Cl, Y = BF4) was obtained.