145934-89-0

Usage

Uses

Used in Chemical Synthesis:
Pyridine, 2-chloro-5-hydrazino(9CI) is used as a reagent for various chemical reactions and synthesis procedures. Its unique structure and reactivity make it a valuable component in the preparation of complex organic molecules and pharmaceutical compounds.
Used in Laboratory Research:
Pyridine, 2-chloro-5-hydrazino(9CI) is used as a research tool in academic and industrial laboratories. Its properties and reactivity are studied to understand its potential applications in different fields, such as material science, pharmaceuticals, and chemical engineering.
Used in Pharmaceutical Development:
Pyridine, 2-chloro-5-hydrazino(9CI) is used as a building block in the development of new pharmaceutical compounds. Its structure and reactivity can be exploited to create novel drug candidates with potential therapeutic applications.
Used in Material Science:
Pyridine, 2-chloro-5-hydrazino(9CI) is used as a component in the synthesis of new materials with unique properties. Its reactivity and structure can contribute to the development of advanced materials for various applications, such as electronics, coatings, and adhesives.

Upstream product

• 31301-51-6 2-chloro-5-fluoropyridine 
• 478361-24-9 N-nitroso-N-(2-chloro-5-pyridyl)glycine 
• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 478361-25-0 2-chloro-5-pyridylsydnone 

Relevant academic research and scientific papers

Extending the scope of the aza-Fischer synthesis of 4- and 6-azaindoles

Fischer indole cyclization has recently been described as an efficient approach to the synthesis of azaindoles bearing electron-donating groups. We now show that this cascade reaction can be very efficient for the formation of a wider range of 4- and 6-azaindoles by using microwave irradiation. Fischer indole cyclization starting from aminopyridines is a very efficient cascade sequence leading to 4- and 6-azaindoles. The scope of the substituents on the pyridine ring was extended to include halogens and to weakly electron-donating substituents by using microwave irradiation. Copyright

CANNABINOID RECEPTOR MODULATORS

Provided are certain methods useful in the treatment of pain comprising administering a compound of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the cannabinoid CB2 receptor.

INDOLIN PHENYLSULFONAMIDE DERIVATIVES

The invention relates to novel substituted indolin phenylsulfonamide derivatives, to a method for the production thereof and to the use thereof in medicaments, especially as potent PPAR-delta activating compounds for the prophylaxis and/or treatment of cardiovascular diseases, especially dyslipidaemia and coronary heart diseases.

Synthesis of halogen-substituted pyridyl and pyrimidyl derivatives of [3,2-c]pyrazolo corticosteroids: Strategies for the development of glucocorticoid receptor mediated imaging agents

Ligands for the glucocorticoid receptor labeled with high-energy isotopes are highly desired for their potential applications in nuclear medical studies of the brain where the dysregulation of this receptor system is thought to be involved in various neurodegenerative disorders. Analogues of the glucocorticoid cortivazol have previously been prepared as target compounds for labeling with high-energy isotopes. However, the phenyl rings of arylpyrazoles of this type are not sufficiently activated for nucleophilic substitution reactions that are generally required for the synthesis of radiohalogenated analogues. Since suitably substituted aromatic nitrogen heterocyclic groups are amenable to nucleophilic substitution, the goal of this study was the synthesis of pyridylpyrazolo and pyrimidylpyrazolo analogues similar to cortivazol that could be labeled with radiohalogens in the pyridine or pyrimidine rings. We describe the synthesis of several [3,2-c]pyrazolo steroids containing pyridyl, halopyridyl, and pyrimidyl substituents at the 2′ position of the pyrazole ring. These compounds were tested for binding to the glucocorticoid receptor and for biological activity in glucocorticoid responsive HeLa cells grown in tissue culture. Of the pyridyl and pyrimidyl derivatives, 2′-(3-pyridyl)-11β,17,21-trihydroxy-16α-methyl-20- oxopregn-4-eno[3,2-c]pyrazole showed superior activity in both assays and it was used as the basis for the synthesis of several analogues that were halogenated in the pyridine ring. These halogenated compounds were all tested for their binding to the glucocorticoid receptor and for their biological activity. One, a fluorinated compound 2′-(2-fluoro-5-pyridyl)-11β, 17,21-trihydroxy-16α-methyl-20-oxopregn-4-eno[3,2-c]pyrazole had excellent activity, considerably better than the potent glucocorticoid dexamethasone. Most importantly, fluorination was achieved using a nucleophilic exchange reaction, a method that is adaptable to radiolabeling with the positron-emitting isotope fluorine-18. Thus, considering its superior biological activity and adaptability for facile radiosynthesis, this target compound has the potential for imaging of glucocorticoid receptor containing tissues using positron emission tomography.

ACTIVE COMPOUNDS

Therapeutically active compounds of the formula: wherein the variables are defined in the specification are provided