145967-58-4

Basic information

• Product Name: (S)-2-((S)-2-Azido-1-benzyloxycarbonyl-ethylamino)-succinic acid dimethyl ester
• Synonyms: (S)-2-((S)-2-Azido-1-benzyloxycarbonyl-ethylamino)-succinic acid dimethyl ester
• CAS NO: 145967-58-4
• Molecular Weight: 364.358
• Mol File: 145967-58-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-2-((S)-2-Azido-1-benzyloxycarbonyl-ethylamino)-succinic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-((S)-2-Azido-1-benzyloxycarbonyl-ethylamino)-succinic acid dimethyl ester(145967-58-4)
• EPA Substance Registry System: (S)-2-((S)-2-Azido-1-benzyloxycarbonyl-ethylamino)-succinic acid dimethyl ester(145967-58-4)

Safety Data

• Hazardous Substances Data: 145967-58-4(Hazardous Substances Data)

Upstream product

• 145967-50-6 benzyl (2S)-3-azido-2-[(tert-butoxycarbonyl)amino]propanoate 
• 59524-02-6 N-tert-butoxycarbonyl-L-serine benzyl ester 
• 1738-72-3 L-serine benzyl ester 
• 70681-41-3 (R)-dimethyl malate 
• 1014986-06-1 (S)-2-Amino-3-azido-propionic acid benzyl ester 

Downstream Products

• 145967-60-8 (2S,6S)-3-Oxo-6-<(phenylmethoxy)carbonyl>-2-piperazineacetic acid methyl ester 

Relevant articles and documents

The synthesis of chiral 3-oxo-6-[(phenylmethoxy)-carbonyl]-2-piperazineacetic acid esters designed for the presentation of an aspartic acid side chain. A subsequent novel Friedel Crafts reaction

The syntheses of (2S, 6R)-, and (2S, 6S)-3-oxo-6-[(phenylmethoxy)carbonyl]-2-piperazineacetic acid methyl esters from L- or D-serine and dimethyl-D-malate are described. Acylation of the (2S, 6S) isomer with 3-methoxyphenylacetyl chloride, hydrogenolysis of the benzyl ester, followed by treatment with oxalyl chloride then aluminum chloride led to an unexpected tricyclic product into which a C2O2 unit had been incorporated.