1459721-13-1

Basic information

• Product Name: (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate
• Synonyms: (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate
• CAS NO: 1459721-13-1
• Molecular Weight: 337.246
• Mol File: 1459721-13-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate(CAS DataBase Reference)
• NIST Chemistry Reference: (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate(1459721-13-1)
• EPA Substance Registry System: (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate(1459721-13-1)

Safety Data

• Hazardous Substances Data: 1459721-13-1(Hazardous Substances Data)

Upstream product

• 59483-84-0 bis(pentafluorophenyl)carbonate 
• 25333-42-0 (R)-quinuclidin-3-ol 

Downstream Products

• 242478-37-1 solifenacin 

Relevant articles and documents

PROCESS OF PREPARING SOLIFENACIN OR SALT THEREOF, AND NOVEL INTERMEDIATE USED IN THE PROCESS

Disclosed herein is a method of preparing solifenacin or a salt thereof, including the steps of: (a) reacting (R)-quinuclidinol with bis(pentafluorophenyl)carbonate in an organic solvent to prepare a solifenacin intermediate, (3R)-1-azabicyclo[2,2,2]oct-3-yl pentafluorophenylcarbonate, and (b) reacting the solifenacin intermediate with (1S)-1-phenyl-1,2,3,4-tetrahydroisoquinoline in an organic solvent to prepare solifenacin. The method is advantageous in that high-purity solifenacin or a salt thereof can be simply and efficiently prepared with high yield using a novel intermediate.