145986-31-8

Basic information

• Product Name: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-5-iodopyrimidin-2(1H)-one
• CAS NO: 145986-31-8
• Molecular Formula: C₈H₁₀IN₃O₃S
• Molecular Weight: 355.1528
• Mol File: 145986-31-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 501.9°C at 760 mmHg
• Flash Point: 257.4°C
• Density: 2.36g/cm³
• Vapor Pressure: 3.53E-12mmHg at 25°C
• Refractive Index: 1.847
• CAS DataBase Reference: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-5-iodopyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-5-iodopyrimidin-2(1H)-one(145986-31-8)
• EPA Substance Registry System: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-5-iodopyrimidin-2(1H)-one(145986-31-8)

Safety Data

• Hazardous Substances Data: 145986-31-8(Hazardous Substances Data)

Upstream product

• 149819-42-1 (+)-(2S,5R)-5-iodo-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N₄-benzoylcytosine 
• 149819-43-2 (-)-(2S,5S)-5-iodo-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N₄-benzoylcytosine 
• 145986-23-8 (+)-(2R,5R)-5-iodo-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N⁴-benzoylcytosine 
• 145913-72-0 (-)-(2R,5S)-5-iodo-1-<2-<<(tert-butyldiphenylsilyl)oxy>methyl>-1,3-oxathiolan-5-yl>-N⁴-benzoylcytosine 

Relevant articles and documents

Structure-Activity Relationships of β-D-(2S,5R)- and α-D-(2S,5S)-1,3-oxathiolanyl Nucleosides as Potential Anti-HIV Agents

The β-D-(2S,5R)- and α-D-(2S,5S)-1,3-oxathiolanylpyrimidine and -purine nucleosides with natural nucleoside configuration were synthesized and evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells.The key intermediate 14, which was uti