146013-28-7

Basic information

• Product Name: 2-THIOPHENESULFONAMIDE, N-(1,1-DIMETHYLETHYL)-5-(2-METHYLPROPYL)-
• Synonyms: 2-THIOPHENESULFONAMIDE, N-(1,1-DIMETHYLETHYL)-5-(2-METHYLPROPYL)-;N-(tert-butyl)-5-isobutylthiophene-2-sulfonaMide;5-Isobutyl-N-tert-butylthiophene-2-sulfonaMide
• CAS NO: 146013-28-7
• Molecular Formula: C₁₂H₂₁NO₂S₂
• Molecular Weight: 275.435
• Mol File: 146013-28-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 375.2±44.0 °C(Predicted)
• Appearance: /
• Density: 1.122±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.03±0.50(Predicted)
• CAS DataBase Reference: 2-THIOPHENESULFONAMIDE, N-(1,1-DIMETHYLETHYL)-5-(2-METHYLPROPYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-THIOPHENESULFONAMIDE, N-(1,1-DIMETHYLETHYL)-5-(2-METHYLPROPYL)-(146013-28-7)
• EPA Substance Registry System: 2-THIOPHENESULFONAMIDE, N-(1,1-DIMETHYLETHYL)-5-(2-METHYLPROPYL)-(146013-28-7)

Safety Data

• Hazardous Substances Data: 146013-28-7(Hazardous Substances Data)

Usage

General Description

2-Thiophenesulfonamide, N-(1,1-dimethylethyl)-5-(2-methylpropyl)- is a chemical compound with a molecular formula C14H21NO2S. It is a sulfonamide derivative, which is a class of organic compounds commonly used as antibiotics and diuretics. This particular compound contains a thiophene ring, a nitrogen atom, and a tert-butyl group, as well as a 2-methylpropyl group. Sulfonamide derivatives have a wide range of pharmacological activities and can be used in the treatment of various diseases, including bacterial infections and hypertension. Further research and testing may be necessary to determine the specific uses and effects of this compound.

Upstream product

• 5674-02-2 2-methylpropylmagnesium chloride 
• 286932-39-6 5-bromothiophene-2-sulphonic acid tert-butylamide 
• 89124-64-1 iodo-2-methylpropane 
• 100342-30-1 thiophene-2-sulfonic acid tert-butylamide 
• 513-38-2 Isobutyl iodide 
• 78-77-3 Isobutyl bromide 

Downstream Products

• 477775-35-2 3-(4-imidazol-1-ylmethylphenyl)-5-isobutyl-N-tert-butylthiophene-2-sulfonamide 
• 477775-36-3 3-[4-[(1H-imidazol-1-yl)methyl]phenyl]-5-isobutylthiophene-2-sulfonamide 
• 477775-14-7 MO 24 
• 912962-74-4 3-(3-((1H-imidazol-1-yl)methyl)phenyl)-N-(tert-butyl)-5-isobutylthiophene-2-sulfonamide 

Relevant articles and documents

Synthesis of 11C-labeled Sulfonyl Carbamates through a Multicomponent Reaction Employing Sulfonyl Azides, Alcohols, and [11C]CO

We describe the development of a new methodology focusing on 11C-labeling of sulfonyl carbamates in a multicomponent reaction comprised of a sulfonyl azide, an alkyl alcohol, and [11C]CO. A number of 11C-labeled sulfonyl carbamates were synthesized and isolated, and the developed methodology was then applied in the preparation of a biologically active molecule. The target compound was obtained in 24±10 % isolated radiochemical yield and was evaluated for binding properties in a tumor cell assay; in vivo biodistribution and imaging studies were also performed. This represents the first successful radiolabeling of a non-peptide angiotensin II receptor subtype 2 agonist, C21, currently in clinical trials for the treatment of idiopathic pulmonary fibrosis.

A Series of Analogues to the AT2R Prototype Antagonist C38 Allow Fine Tuning of the Previously Reported Antagonist Binding Mode

We here report on our continued studies of ligands binding to the promising drug target angiotensin II type 2 receptor (AT2R). Two series of compounds were synthesized and investigated. The first series explored the effects of adding small subs

NEW TRICYCLIC ANGIOTENSIN II AGONISTS

There is provided compounds of formula (I) wherein the dotted line, X1, X2, X3, A, Y1, Y2, Y3, Y4, Z1, Z2, R2 and R3 have meanings giv