146028-83-3

Upstream product

• 32233-43-5 2-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]ethanol 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 116996-52-2 (2S)-4-O-(tert-butyldiphenylsilyl)butane-1,2,4-triol 
• 159142-17-3 (S)-1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-ol 
• 159142-19-5 (R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-2,3-dihydrooxazol-2-one 
• 159142-18-4 (R)-3-(1-Benzyloxy-4-tert-butyldiphenylsilyloxybutan-2-yl)-oxazolidine-2,4-dione 
• 133218-79-8 (1'R,2'R)-1-O-tert-butyldiphenylsilyl-2-<2'-benzenesulfonyl-2'-(trimethylsilyl)methylcyclopropyl>ethan-1-ol 
• 133218-82-3 (3S,5R)-1-O-tert-butyldiphenylsilyl-5-benzenesulfonyl-6-(trimethylsilyl)hexane-1,3-diol 
• 133218-77-6 (3S,5S)-1-O-tert-butyldiphenylsilyl-5-benzenesulfonyl-6-(trimethylsilyl)hexane-1,3-diol 
• 133218-83-4 (3S,5R)-1-O-tert-butyldiphenylsilyl-3-O-methanesulfonyl-5-benzenesulfonyl-6-(trimethylsilyl)hexane-1,3-diol 
• 133218-78-7 (3S,5S)-1-O-tert-butyldiphenylsilyl-3-O-methanesulfonyl-5-benzenesulfonyl-6-(trimethylsilyl)hexane-1,3-diol 
• 120341-92-6 tert-Butyl-(2-{(2S,4S)-4-[(2S,4S)-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-1,5-dioxa-spiro[5.5]undec-2-ylmethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-ethoxy)-diphenyl-silane 
• 120341-89-1 (S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-3-[2-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-[1,3]dithian-2-yl]-propan-2-ol 
• 120341-90-4 (S)-5-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-4-hydroxy-pentan-2-one 
• 120341-91-5 (2R,4S)-1-{(2R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-1,5-dioxa-spiro[5.5]undec-2-yl}-5-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-pentane-2,4-diol 
• 120341-93-7 (2S,4S,6S,8S,10S)-12-(tert-Butyl-diphenyl-silanyloxy)-dodecane-1,2,4,6,8,10-hexaol 

Relevant academic research and scientific papers

A CONVERGENT GENERAL SYNTHETIC PROTOCOL FOR SYN-1,3-POLYOLS

A method for the stereoselective synthesis of syn-1,3-polyols using a chiral building block 1 is described.High syn-stereoselectivity in the reduction of β-hydroxy ketones was achieved using lithium aluminum hydride-lithium iodide.

NITROSATED GLUTAMIC ACID COMPOUNDS, COMPOSITIONS AND METHODS OF USE

The invention describes novel nitrosated glutamic acid compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated glutamic acid compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one nitrosated glutamic acid compound, and, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; (k) treating nephropathy; (1) treating diseases resulting from elevated levels of gamma-glutamyl transpeptidase and (m) the targeted delivery of compounds and nitric oxide to organs, cells or tissues containing the enzyme gamma-glutamyl transpeptidase.

A stereoselective synthesis of verbalactone-determination of absolute stereochemistry

A total synthesis of verbalactone has been achieved starting from l-malic acid. A total synthesis of verbalactone has been achieved starting from l-malic acid. The two appropriately protected acid and alcohol segments were prepared from l-malic acid and l

Sequential sp2-sp2 coupling reactions in polyene macrolide synthesis. A novel approach to macrolactin A

A combination of two intermolecular sp2-sp2 (Stille and Suzuki) coupling reactions, is employed to elaborate the precursor 2, used in an intramolecular Stille sp2-2 macrocyclisation leading to the hexaene macrol

Diastereoselective synthesis of 2,5-disubstituted 3-hydroxypyrrolidine and 2,6-disubstituted 3-hydroxypiperidine derivatives by radical cyclisation; synthesis of (+)-bulgecinine and (-)-desoxoprosopinine

Cyclisation of the O-stannyl ketyl, generated from the aldehyde 17 by reaction with tributyltin hydride in the presence of AIBN, gives the 5-benzyloxymethyl-7-hydroxypyrrolooxazolidin-2-ones as a diastereoisomeric mixture of 7α-ol 18 and 7β-ol 19 (2:1), with high diastereoselectivity with respect to the 5,7a positions. (+)-Bulgecinine 8 is enantioselectively synthesised by stereospecific reduction of the ketone 20, derived from compounds 18 and 19. In a similar way, cyclisation of compound 40 gives a 2:1 mixture of compounds 41 and 42. Conversion of compound 41 into (-)-desoxoprosopinine 9 is successfully achieved.

A New Route to Chiral Pyrrolidines via Radical Cyclisation; Enantioselective Synthesis of (+)-Bulgecinine

Reaction of the aldehyde 11 with tributyltin hydride in the presence of AIBN gave a mixture of 12 and 13, which successfully led to (+)-bulgecinine 3.

Enantioselective synthesis of the methylenecyclopropane derivative related to hypoglycine, from malic acid

Synthesis of (S)-methylenecyclopropaneacetic acid starting from L-(-)-malic acid, via (2S)-O-tert-butyldimethylsilyl-1,2-epoxybutan-4-ol and 1-O-tert-butyldiphenylsilyl-5-benzenesulfonyl-6-trimethylsilylhexane-1,3-diols as the key intermediates, is descri