146032-79-3

Basic information

• Product Name: SC-51322
• Synonyms: SC-51322;8-Chloro-2-[3-[(2-furanylmethyl)thio]-1-oxopropyl]-dibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylicacidhydrazide;8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic Acid 2-[3-[(2-FuranylMethyl) thio]-1-oxopropyl]hydrazide
• CAS NO: 146032-79-3
• Molecular Formula: C22H20ClN3O4S
• Molecular Weight: 457.93
• Product Categories: Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 146032-79-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: 112-114°C
• Appearance: white to off-white/
• Storage Temp.: Store at +4°C
• Solubility: DMSO: ≥10mg/mL
• CAS DataBase Reference: SC-51322(CAS DataBase Reference)
• NIST Chemistry Reference: SC-51322(146032-79-3)
• EPA Substance Registry System: SC-51322(146032-79-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• RTECS: HQ4002000
• HazardClass: 6.1
• Hazardous Substances Data: 146032-79-3(Hazardous Substances Data)

Usage

Description

The prostaglandin E2 (PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg. It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089. SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 μM.

Chemical Properties

Off-White Solid

Uses

A selective E-prostanoid receptor subtype 1 (EP1) receptor antagonist which shows antihypertensive effects.