146037-75-4Relevant academic research and scientific papers
Kinetic Resolution of Racemic Carboxylic Acids and Alcohols with Homochiral Alcohols and Carboxylic Acids, Respectively, and the Mukaiyama or Palomo Reagents
Mazon, Angel,Najera, Carmen,Yus, Miguel,Heumann, Andreas
, p. 1455 - 1466 (2007/10/02)
The Mukaiyama and Palomo reagents have been used for the kinetic resolution of racemic carboxylic acids or alcohols with homochiral alcohols or carboxylic acids, respectively, in the presence of triethylamine.Thus, enantiomerically enriched carboxylic acids (e.e.68percent), alcohols (e.e.41percent) or diastereoisomerically enriched esters (d.e.84percent) are obtained.
Kinetic resolution of racemic alcohols with chiral carboxylic acids and dicyclohexylcarbodiimide
Chinchilla,Najera,Yus,Heumann
, p. 851 - 854 (2007/10/02)
The DCC-esterification method has been used to kinetically resolve racemic mixtures of alcohols. With simple chiral carboxylic acids, such as O-aryl lactic acids, in the presence of various basic catalysts, mixtures of the enantiomerically enriched alcohols (e.e. 50%) and the corresponding esters (d.e. 70%) have been obtained.
