146041-06-7Relevant academic research and scientific papers
DIE ANLAGERUNG VON MERCAPTOCARBONSAEUREN AN 3-THIAZOLINE UND ANSCHLIESSENDE LACTAMISIERUNG
Koepper, Sabine,Lindner, Karen,Martens, Juergen
, p. 10277 - 10292 (1992)
The reaction of 3-thiazolines 1a-c with α- or β-mercaptocarboxylic acids leads to bicyclic lactams 2-4.Depending on the reaction conditions diastereomeric mixtures 2b, 3, 4a,b are formed.The synthesis of the latter can be explained by a two-step mechanism.The configuration and conformation of the diasteremers is deducted by (1)H, (13)C-NMR spectroscopy and NOE experiments.
