146060-35-7

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 146060-34-6 fluoroiodomethyl piperidino ketone 
• 321-77-7 fluorochloromethyl piperidino ketone 
• 110-89-4 piperidine 

Relevant academic research and scientific papers

Diethylzinc-mediated addition of 2,2-dibromo-2-fluoroacetamides to carbonyl compounds: Synthesis of α-bromo-α-fluoro-β-hydroxy amides and/or (Z)-fluorovinyl amides

We describe straightforward routes either to α-bromo-α-fluoro- β-hydroxy amides or to (Z)-α-fluoroacrylamides starting from aldehydes, ketones or imine and 2,2-dibromo-2-fluoroacetamides. Depending on the nature of the amide, these diethylzinc-mediated additions to aldehydes, ketones or imine afford selective access either to bromofluorohydrins or to (Z)-α-fluoroacrylamides. The corresponding products were obtained in moderate to very good yields and the configurations of both products were confirmed by X-ray analyses. Reactions between aldehydes, ketones or imines and 2,2-dibromo-2-fluoroacetamides, a new class of fluorinated reagent, allow straightforward selective access to α-bromo-α-fluoro-β-hydroxy amides and/or (Z)-α-fluoroacrylamides with moderate to excellent yields. Copyright

Synthesis of 1-Fluoro-2-Phenylvinyl Piperidino Ketones

A new palladium-catalysed synthesis of 1-fluoro-2-phenylvinyl piperidino ketones is described.