146060-66-4Relevant articles and documents
Addition of 2-(chloromagnesiomethyl)-2-alkenyl ethers to epoxides followed by Pd(0)-catalyzed cyclization: A one-pot synthesis of 3-methylenetetrahydropyrans
Van Der Louw,Van Der Baan,Out,De Kanter,Bickelhaupt,Klumpp
, p. 9901 - 9916 (1992)
Addition of 2-(chloromagnesiomethyl)-2-propenyl ethers 1a and 1b to epoxides 3 affords ring opening products 6 or 7 which are converted by Pd(0) to 3-methylenetetrahydropyrans 9. Cyclization of the addition products is best effected by a catalyst system generated in situ from Pd(OAc)2 and (i-PrO)3P.