146117-78-4

Basic information

• Product Name: trans-(±)-8-Chloro-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one
• Synonyms: LY-191704; (4aS,10bS)-8-chloro-4-methyl-1,4,4a,5,6,10b-hexahydrobenzo[f]quinolin-3(2H)-one
• CAS NO: 146117-78-4
• Molecular Formula: C₁₄H₁₆ClNO
• Molecular Weight: 249.7359
• Mol File: 146117-78-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 413.9°C at 760 mmHg
• Flash Point: 204.1°C
• Density: 1.202g/cm³
• Vapor Pressure: 4.65E-07mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: trans-(±)-8-Chloro-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: trans-(±)-8-Chloro-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one(146117-78-4)
• EPA Substance Registry System: trans-(±)-8-Chloro-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one(146117-78-4)

Safety Data

• Hazardous Substances Data: 146117-78-4(Hazardous Substances Data)

Upstream product

• 1878-66-6 4-chlorophenylacetic Acid 
• 152237-49-5 cis-dl-8-bromo-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 148905-81-1 (-)-(4AR)-(10BR)-8-chloro-4-(S-α-methylbenzyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 148835-22-7 8-Chloro-4-((S)-1-phenyl-ethyl)-1,4,5,6-tetrahydro-2H-benzo[f]quinolin-3-one 
• 148835-23-8 (6-Chloro-3,4-dihydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-amine 
• 17556-18-2 6-chloro-3,4-dihydro-1H-naphthalen-2-one 
• 161320-13-4 methyl 3-<(2-R-N-tert-butyloxycarbonylmethylamino-6-chloro-S-1,2,3,4-tetrahydronaphthalen)-1-yl>propionate 
• 152323-03-0 trans-dl-8-chloro-4-methyl-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 161320-16-7 ethyl 3-<(2-R-N-tert-butyloxycarbonylmethylamino-6-chloro-S-1,2,3,4-tetrahydronaphtalen)-1-yl>-propionate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 148905-77-5 (+)-(4AR)-(10BR)-8-chloro-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 
• 74-88-4 methyl iodide 
• 148835-24-9 (+)-(4AS)-(10BS)-8-chloro-4-(S-α-methylbenzyl)-1,2,3,4,4a,5,6,10b-octahydrobenzo[f]quinolin-3-one 

Downstream Products

• 146117-78-4 bexlosteride 

Relevant articles and documents

Resolution of δ-lactams provides access to nonracemic benzoquinolinones: The synthesis of LY300502 and LY300503

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Method of preventing prostatic cancer development

A series of benzoquinolin-3-ones are pharmaceuticals effective in preventing the development of prostatic cancer, or preventing or treating the metastasis to bone of prostatic cancer.

Process for preparation of benzo[f]quinolinones

A series of benzoquinolin-3-ones are pharmaceuticals effective in treating conditions consequent on both Type I and Type II 5α-reductase and their preparation is disclosed.