146136-05-2Relevant academic research and scientific papers
Method for preparing some 1-adamantancecarboxamides
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Page column 4, (2010/01/30)
This invention relates to a method for the novel preparation of 1-adamantanecarboxamides and 1-adamantaneacetamides. Adamantanecarboxamides and adamantaneacetamides are prepared in high yields (80-100%) by treating adamantanecarboxylic acid and adamantaneacetic acid with N,N-diethyl-1,1,2,3,3,3-hexafluoropropylamine, followed by addition of aqueous ammonia or the appropriate amine. The procedure, carried out at ambient temperature using common laboratory equipment, is both convenient and rapid, requiring no more than one or two hours. Several reactions can be carried out simultaneously.
KINETICS OF THE ACYLATION OF MONOSUBSTITUTED AROMATIC AMINES BY ACID CHLORIDES
Khardin, A. P.,Novakov, I. A.,Radchenko, S. S.,Brel', N. A.,Chegolya, A. S.,et al.
, p. 1492 - 1495 (2007/10/02)
The kinetics of the acylation of p-toluidine and 1-(4-aminophenyl)adamantane by acid chlorides were investigated.It was established that adamantanecarbonyl chlorides have lower reactivity than cyclohexanecarbonyl chlorides and aliphatic acid chlorides.
