146137-85-1 Usage
General Description
4-IODO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER is a chemical compound with the molecular formula C11H7IO2S. It is an organic ester that contains a benzothiophene ring with a carboxylic acid and a methyl ester functional group attached at the 2-position and an iodine atom at the 4-position. 4-IODO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID METHYL ESTER has potential applications in the field of organic chemistry, pharmaceuticals, and materials science. It may be used as a building block for the synthesis of other organic compounds, particularly those with biological or pharmacological activity. Additionally, it may also be used as a reagent in chemical reactions and synthesis pathways. Due to its structural features, it is important to handle this compound with caution and in accordance with proper safety protocols.
Check Digit Verification of cas no
The CAS Registry Mumber 146137-85-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,1,3 and 7 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 146137-85:
(8*1)+(7*4)+(6*6)+(5*1)+(4*3)+(3*7)+(2*8)+(1*5)=131
131 % 10 = 1
So 146137-85-1 is a valid CAS Registry Number.
146137-85-1Relevant articles and documents
A benzo[b]thiophene-based selective type 4 S1P receptor agonist
Hur, Wooyoung,Rosen, Hugh,Gray, Nathanael S.
supporting information, p. 1 - 5 (2016/12/09)
S1P receptors (S1PR1-5) are a group of GPCRs activated by a high affinity binding with S1P that have important roles in the regulation of the immune system. A potent S1PR agonist FTY720 is an immunomodulator used to treat multiple sclerosis and several ‘second generation’ drugs are under clinical development. Subtype-selective agonists have been reported for each S1PR isotype, some of which are used as pharmacological tools for functional studies. Here we report the discovery and initial characterization of compound 5c, a benzo[b]thiophene amino carboxylate which exhibits potent and selective agonist activity for S1PR4. Compound 5c has an EC50= 200 nM as an agonist in GTPγ35S binding assay for S1PR4 and exhibits no activity against S1PR1,2,3,5. We confirmed its potent activity and decent S1PR subtype selectivity using biochemical and cellular assays.
UROKINASE INHIBITORS
-
, (2008/06/13)
Disclosed are benzothiophene and thienothiophene derivatives useful for inhibiting urokinase activity.
