1461634-28-5

Upstream product

• 22731-72-2 1-(4-nitrophenyl)prop-2-en-1-one 
• 120801-75-4 trimethylsilyl-2,2-difluoro-2-(fluorosulphonyl)acetate 
• 100-19-6 (4-nitrophenyl)ethanone 

Downstream Products

• 1461634-39-8 (5-fluoro-2-methyl-1H-pyrrol-3-yl)(4-nitrophenyl)methanone 
• 1529771-20-7 4,4,4-trifluoro-1-(4-nitrophenyl)butan-1-one 
• 1529771-26-3 4-chloro-4,4-difluoro-1-(4-nitrophenyl)butan-1-one 
• 1529771-36-5 4-bromo-4,4-difluoro-1-(4-nitrophenyl)butan-1-one 

Relevant academic research and scientific papers

Boron-trihalide-promoted regioselective ring-opening reactions of gem-difluorocyclopropyl ketones

Boron trihalide-promoted ring-opening reactions of gem-difluorocyclopropyl ketones to give the corresponding β-trifluoromethyl ketones and β-halodifluoromethyl ketones were described. It was found that boron trihalides act as both Lewis acids and nucleophiles and the proximal bond prefers to cleave in this transformation.

A novel reaction of gem-difluorocyclopropyl ketones with nitriles leading to 2-fluoropyrroles

The CF3SO3H-promoted ring opening of gem-difluorocyclopropyl ketones prefers to undergo proximal bond cleavage and the subsequent cyclization with nitriles occurred smoothly to give 2-fluoropyrroles.