146198-68-7

Basic information

• Product Name: 2-(4-FLUORO-BENZOYL)-3-OXO-BUTYRIC ACID ETHYL ESTER
• Synonyms: 2-(4-FLUORO-BENZOYL)-3-OXO-BUTYRIC ACID ETHYL ESTER;AKOS MSC-0293
• CAS NO: 146198-68-7
• Molecular Formula: C₁₃H₁₃FO₄
• Molecular Weight: 252.24
• Mol File: 146198-68-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 336.6±27.0 °C(Predicted)
• Appearance: /
• Density: 1.208±0.06 g/cm3(Predicted)
• PKA: 5.85±0.27(Predicted)
• CAS DataBase Reference: 2-(4-FLUORO-BENZOYL)-3-OXO-BUTYRIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-BENZOYL)-3-OXO-BUTYRIC ACID ETHYL ESTER(146198-68-7)
• EPA Substance Registry System: 2-(4-FLUORO-BENZOYL)-3-OXO-BUTYRIC ACID ETHYL ESTER(146198-68-7)

Safety Data

• Hazardous Substances Data: 146198-68-7(Hazardous Substances Data)

Usage

Molecular Weight

244.23 g/mol

Functional Groups

Ethyl ester, fluoro-benzoyl, oxo (ketone)

Usage

Intermediate in the synthesis of pharmaceuticals and agrochemicals
Reagent in organic synthesis
Building block for the synthesis of various pharmaceuticals
Applications in the production of anti-inflammatory and analgesic drugs
Structurally similar to acetoacetic acid ethyl ester

Upstream product

• 456-22-4 4-Fluorobenzoic acid 
• 141-97-9 ethyl acetoacetate 
• 403-43-0 4-fluorobenzoyl chloride 

Downstream Products

• 1736-24-9 5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid 
• 1961-31-5 5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid amide 
• 146198-53-0 ethyl N-(4-fluorobenzoyl)acetyl-N-(4-methoxy)benzylglycinate 
• 146198-60-9 1-(4-methoxy)benzyl-3-(4-fluoro)benzoyl-2,4-pyrrolidindione 
• 146198-57-4 N-(4-methoxy)benzyl-N-(4-fluorobenzoyl)acetyl-glycine 
• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 
• 1644-03-7 5-(4-fluoro-phenyl)-3-methyl-isoxazole-4-carboxylic acid ethyl ester 

Relevant articles and documents

PYRROLOPYRIDAZINE DERIVATIVES

The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.