14621-03-5Relevant articles and documents
Synthesis, crystal structure, DNA-binding and cytotoxicity in vitro of novel cis-Pt(II) and trans-Pd(II) pyridine carboxamide complexes
Shi, Chun-Yue,Gao, En-Jun,Ma, Shuang,Wang, Mei-Lin,Liu, Qi-Tao
, p. 7250 - 7254 (2010)
In an attempt to establish fundamental structure-activity relationships (SAR) of Pt/Pd-based anti-tumour compounds, we have recently designed monodentate pyridyl amide ligand containing central amide units which possess external metal co-ordinating pyridyl group and internal amide functionality. It was prepared in one step from commercially available compounds in moderate to good yield. Surprisingly, treatment of K2[MCl4] [M = Pt(II), Pd(II)] with ligand N-(4-chlorophenyl)-3-pyridinecarboxamide (L) in the same reaction condition affords two different hydrogen-bonded polymers: cis-[PtL2Cl2]·CH3OH·DMF (1) and trans-[PdL2Cl2]·2DMF (2). Fluorescence analysis indicates that the two complexes can bind to fish sperm DNA (FS-DNA) and gel electrophoresis assay demonstrates the ability of the complexes to cleave the pBR322 plasmid DNA. The two complexes exhibit cytotoxic specificity and significant cancer cell inhibitory rate. Furthermore, cytotoxicity values are higher in the case of cis-Pt(II) complex than trans-Pd(II) complex in four different cancer cell lines.
Aminocarbonylation of N -Containing Heterocycles with Aromatic Amines Using Mo(CO) 6
Mamone, Marius,Aziz, Jessy,Le Bescont, Julie,Piguel, Sandrine
, p. 1521 - 1526 (2018/01/27)
We describe herein the palladium-catalyzed aminocarbonylation of nitrogen-containing heterocycles with aniline derivatives using molybdenum hexacarbonyl as a CO solid source, expanding the scope of the limited examples. This method is compatible with a variety of substitutions on the aniline moiety. The simple reaction conditions include easily available Pd(dppf)Cl 2 catalyst, DBU as base in DMF at 120 °C for 3 hours in sealed tube thereby leading to the isolation of 21 compounds with yields ranging from 18 to 82%. We also show that double aminocarbonylation reactions are possible in satisfactory yields regarding both coupling partners.
An organometallic complex revealing an unexpected, reversible, temperature induced SC-SC transformation
Taylor, Rupert G. D.,Yeo, Benjamin R.,Hallett, Andrew J.,Kariuki, Benson M.,Pope, Simon J. A.
, p. 4641 - 4652 (2014/05/20)
A reversible, temperature driven phase transformation that takes place at ca. 180 K, in a single-crystal to single-crystal manner, has been observed for a monometallic transition metal coordination complex based on a fac-Re(CO) 3 core, with a c
