146224-62-6

Basic information

• Product Name: Benzamide, 4-amino-3-hydroxy- (9CI)
• Synonyms: Benzamide, 4-amino-3-hydroxy- (9CI);4-amino-3-hydroxybenzamide
• CAS NO: 146224-62-6
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15062
• Product Categories: AMIDE
• Mol File: 146224-62-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: Benzamide, 4-amino-3-hydroxy- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-amino-3-hydroxy- (9CI)(146224-62-6)
• EPA Substance Registry System: Benzamide, 4-amino-3-hydroxy- (9CI)(146224-62-6)

Safety Data

• Hazardous Substances Data: 146224-62-6(Hazardous Substances Data)

Upstream product

• 619-14-7 3-hydroxy-4-nitro-benzoic acid 

Relevant articles and documents

Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors

Human DNA topoisomerase II is one of the major targets in anticancer therapy, however ATP-competitive inhibitors of this target have not yet reached their full potential. ATPase domain of human DNA topoisomerase II belongs to the GHKL ATPase superfamily and shares a very high 3D structural similarity with other superfamily members, including bacterial topoisomerases. In this work we report the discovery of a new chemotype of ATP-competitive inhibitors of human DNA topoisomerase IIα that were discovered through screening of in-house library of ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV. Systematic screening of this library provided us with 20 hit compounds. 1,2,4-Substituted N-phenylpyrrolamides were selected for a further exploration which resulted in 13 new analogues, including 52 with potent activity in relaxation assay (IC50 = 3.2 μM) and ATPase assay (IC50 = 0.43 μM). Cytotoxic activity of all hits was determined in MCF-7 cancer cell line and the most potent compounds, 16 and 20, showed an IC50 value of 8.7 and 8.2 μM, respectively.

Amino-benzoic acids and derivatives, and methods of use

The present invention relates to compounds, compositions and methods for inhibiting nonenzymatic cross-linking (protein aging). Accordingly, a composition is disclosed which comprises an agent capable of inhibiting the formation of advanced glycosylation endproducts of target proteins by reacting with a carbonyl moiety of the early glycosylation product of such target proteins formed by their initial glycosylation. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.