1462249-75-7 Usage
Uses
Used in Cancer Treatment:
PFK-158 is used as an inhibitor for PFKFB3 in cancer treatment, specifically targeting leukemia cells. It has shown to effectively inhibit the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduce tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model.
Used in Enhancing Antibody Activity:
PFK-158 is used as an enhancer for the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma. By inhibiting PFKFB3, PFK-158 can potentially improve the efficacy of the anti-CTLA-4 antibody, providing a more effective treatment option for melanoma patients.
Used in Research and Development:
PFK-158 is used as a research tool for studying the role of PFKFB3 in glycolysis and its potential as a therapeutic target in various types of cancer. Its ability to inhibit PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively) makes it a valuable compound for investigating the underlying mechanisms of cancer cell metabolism and the development of novel cancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 1462249-75-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,6,2,2,4 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1462249-75:
(9*1)+(8*4)+(7*6)+(6*2)+(5*2)+(4*4)+(3*9)+(2*7)+(1*5)=167
167 % 10 = 7
So 1462249-75-7 is a valid CAS Registry Number.
1462249-75-7Relevant academic research and scientific papers
PFKFB3 INHIBITOR AND METHODS OF USE AS AN ANTI-CANCER THERAPEUTIC
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, (2013/10/21)
A novel compound, (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one, is provided herein. (E)-1-(pyridyn-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)-prop-2-en-1-one is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-biphosphata
