1462321-89-6

Basic information

• Product Name: (R)-7-bis(3,5-dimethylphenyl)phosphino-7'-bis(m-xylyl)phosphinyl-1,1'-spirobiindane
• CAS NO: 1462321-89-6
• Molecular Weight: 716.883
• Mol File: 1462321-89-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 856.5±65.0 °C(Predicted)
• CAS DataBase Reference: (R)-7-bis(3,5-dimethylphenyl)phosphino-7'-bis(m-xylyl)phosphinyl-1,1'-spirobiindane(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-7-bis(3,5-dimethylphenyl)phosphino-7'-bis(m-xylyl)phosphinyl-1,1'-spirobiindane(1462321-89-6)
• EPA Substance Registry System: (R)-7-bis(3,5-dimethylphenyl)phosphino-7'-bis(m-xylyl)phosphinyl-1,1'-spirobiindane(1462321-89-6)

Safety Data

• Hazardous Substances Data: 1462321-89-6(Hazardous Substances Data)

Usage

Uses

Chiral ligand introduced in collaboration with Prof. Steve Zhou and coworkers, has shown utility in asymmetric Heck reactions for both intra and intermolecular C-C bond formation with various triflates and halides.

Upstream product

• 187344-92-9 bis(3,5-dimethylphenyl)phosphine oxide 
• 556-96-7 5-bromo-1,3-xylene 
• 1403360-57-5 (R)-7-bis(3,5-dimethylphenyl)phosphino-7′-trifluoromethanesulfonyloxy-1,1′-spirobiindane 

Relevant articles and documents

SPIRO-1,1'-BIINDANE-7,7-BISPHOSPHINE OXIDES AS HIGHLY ACTIVE SUPPORTING LIGANDS FOR PALLADIUM-CATALYZED ASYMMETRIC HECK REACTION

The present invention relates to catalyst complexes comprising palladium (Pd) and at least one spiro-1,1 '-biindane-7,7'- bisphosphine oxide ligand as disclosed herein, and their use. The present invention is further directed to the asymmetric Pd-catalyzed covalent carbon-carbon single bond formation from aryl, heteroaryl and alkenyl triflates and halides and olefins utilising the said catalyst complexes.

Palladium-catalyzed asymmetric intermolecular cyclization

Domino cyclization: Alkylpalladium intermediates in an asymmetric Heck reaction were intercepted by a second alkene to give tricyclic products with high enantioselectivity (see scheme; Boc=tert-butoxycarbonyl). The method was applied to the asymmetric syn