146253-94-3Relevant academic research and scientific papers
Conversion of N-Acyl-2,3-dihydro-4-pyridones to 4-Chloro-1,2-dihydropyridines Using the Vilsmeier Reagent. Synthesis of (-)-Coniine and (+/-)-Lupinine
Al-awar, Rima S.,Joseph, Sajan P.,Comins, Daniel L.
, p. 7732 - 7739 (2007/10/02)
The full details are given of a study on the conversion of dihydropyridones of the type 3 to 4-chloro-1,2-dihydropyridines 4 using a Vilsmeier reagent.The use of 1 equiv of Vilsmeier reagent under mild conditions (ClCHCCl2, rt) transformed several racemic
Conversion of N-acyl-2,3-dihydro-4-pyridones to 4-chloro-1,2-dihydropyridines using the Vilsmeier reagent
Al-Awar,Joseph,Comins
, p. 7635 - 7638 (2007/10/02)
N-Acyl-2,3-dihydro-4-pyridones are converted to 1-acyl-4-chloro-1,2-dihydropyridines in one step using one equivalent of Vilsmeier reagent. This conversion was utilized in an asymmetric synthesis of (-)-coniine.
