146275-18-5

Basic information

• Product Name: trans-3'-Hydroxycotinine-N-b-D-glucuronide
• Synonyms: trans-3-Hydroxycotinine glucuronide;trans-3'-Hydroxy Cotinine-d3 N-β-D-Glucuronide ;1-β-D-Glucopyranuronosyl-3-[(2S,4R)-4-hydroxy-1-Methyl-5-oxo-2-pyrrolidinyl]pyridiniuM;1-β-D-Glucopyranuronosyl-3-[(2S,4R)-4-hydroxy-1-Methyl-5-oxo-2-pyrrolidinyl]pyridiniuM Inner Salt;trans-3'-Hydroxycotinine-N-glucuronide
• CAS NO: 146275-18-5
• Molecular Formula: C16H20N2O8
• Molecular Weight: 368.34
• Product Categories: Glucuronides;Metabolites;Nicotine Derivatives;Heterocycles;Metabolites & Impurities;Mutagenesis Research Chemicals;Glucuronides, Heterocycles, Metabolites & Impurities, Mutagenesis Research Chemicals
• Mol File: 146275-18-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 188-189°C dec.
• Boiling Point: 699.2°Cat760mmHg
• Flash Point: 376.7°C
• Appearance: /
• Density: 1.58g/cm³
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: Water (Slightly)
• CAS DataBase Reference: trans-3'-Hydroxycotinine-N-b-D-glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: trans-3'-Hydroxycotinine-N-b-D-glucuronide(146275-18-5)
• EPA Substance Registry System: trans-3'-Hydroxycotinine-N-b-D-glucuronide(146275-18-5)

Safety Data

• Hazardous Substances Data: 146275-18-5(Hazardous Substances Data)

Usage

Description

Trans-3'-Hydroxycotinine-N-b-D-glucuronide is a significant metabolite of nicotine, which is primarily found in humans. It is a white solid and is classified as a carcinogen due to its potential to cause cancer.

Uses

Used in Pharmaceutical Research:
Trans-3'-Hydroxycotinine-N-b-D-glucuronide is used as a research compound for understanding the metabolism of nicotine and its potential effects on human health. As a major metabolite of nicotine, it plays a crucial role in studying the pharmacokinetics and pharmacodynamics of nicotine, which can be vital for the development of smoking cessation therapies and other related treatments.
Used in Toxicology Studies:
In toxicology, trans-3'-Hydroxycotinine-N-b-D-glucuronide is used as a biomarker to assess the level of nicotine exposure in individuals. This metabolite helps researchers and healthcare professionals evaluate the risks associated with tobacco use and exposure to secondhand smoke.
Used in Analytical Chemistry:
As a white solid, trans-3'-Hydroxycotinine-N-b-D-glucuronide can be used in analytical chemistry for the development of assays and testing methods to detect and quantify nicotine and its metabolites in biological samples. This can be essential for monitoring nicotine levels in clinical settings and research studies.
Used in Public Health Initiatives:
Trans-3'-Hydroxycotinine-N-b-D-glucuronide is used as an indicator in public health initiatives aimed at raising awareness about the dangers of tobacco use and promoting smoking cessation. Understanding the presence and effects of this metabolite can help inform educational campaigns and support programs for those seeking to quit smoking.
Used in Environmental Studies:
In environmental studies, trans-3'-Hydroxycotinine-N-b-D-glucuronide can be used to monitor the presence of nicotine and its metabolites in various ecosystems, such as soil, water, and air. This information can be valuable for assessing the impact of tobacco use on the environment and developing strategies to mitigate its effects.