146278-32-2Relevant academic research and scientific papers
Identification of Highly Potent Human Immunodeficiency Virus Type-1 Protease Inhibitors against Lopinavir and Darunavir Resistant Viruses from Allophenylnorstatine-Based Peptidomimetics with P2 Tetrahydrofuranylglycine
Hidaka, Koushi,Kimura, Tooru,Sankaranarayanan, Rajesh,Wang, Jun,McDaniel, Keith F.,Kempf, Dale J.,Kameoka, Masanori,Adachi, Motoyasu,Kuroki, Ryota,Nguyen, Jeffrey-Tri,Hayashi, Yoshio,Kiso, Yoshiaki
, p. 5138 - 5153 (2018/06/11)
The emergence of drug-resistant HIV from a widespread antiviral chemotherapy targeting HIV protease in the past decades is unavoidable and provides a challenge to develop alternative inhibitors. We synthesized a series of allophenylnorstatine-based peptid
Potent HIV Protease Inhibitors: The Development of Tetrahydrofuranylglycines as Novel P2 Ligands and Pyrazine Amides as P3-Ligands
Ghosh, Arun K.,Thompson, Wayne J.,Holloway, M. Katharine,McKee, Sean P.,Duong, Tien T.,et al.
, p. 2300 - 2310 (2007/10/02)
A series of protease inhibitors bearing constrained unnaturel amino acids at the P2-position and novel heterocycles at the P3-position of compound 1 (Ro 31-8959) were synthesized, and their in vitro enzyme inhibitory and antiviral ac
