14628-57-0

Basic information

• Product Name: 4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE
• Synonyms: 4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE;4-CHLORO-5-METHOXY-2-METHYLPYRIDAZIN-3(2H)-ONE;4-CHLORO-5-METHOXY-2-METHYLPYRIDAZIN-3-ONE
• CAS NO: 14628-57-0
• Molecular Formula: C₆H₇ClN₂O₂
• Molecular Weight: 174.58
• Product Categories: Pyrazines, Pyrimidines & Pyridazines;Pyrazines, Pyrimidines & Pyridazines
• Mol File: 14628-57-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 151-153°C
• Boiling Point: 268 °C at 760 mmHg
• Flash Point: 115.9 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 0.00789mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE(14628-57-0)
• EPA Substance Registry System: 4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE(14628-57-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 14628-57-0(Hazardous Substances Data)

Usage

General Description

4-Chloro-5-methoxy-2-methyl-2,3-dihydropyridazin-3-one is a chemical compound with the molecular formula C7H8ClNO2. It is a derivative of the dihydropyridazin-3-one family and is characterized by the presence of a chloro, methoxy, and methyl group on its structure. 4-CHLORO-5-METHOXY-2-METHYL-2,3-DIHYDROPYRIDAZIN-3-ONE has been studied for its potential pharmaceutical properties, including its potential as an anti-inflammatory and antimicrobial agent. It has also been investigated for its role in the development of new drug candidates for various medical conditions. Further research and studies are being conducted to explore the potential applications and properties of 4-Chloro-5-methoxy-2-methyl-2,3-dihydropyridazin-3-one.

InChI:InChI=1/C6H7ClN2O2/c1-9-6(10)5(7)4(11-2)3-8-9/h3H,1-2H3

Upstream product

• 77-78-1 dimethyl sulfate 
• 63910-43-0 4-chloro-5-methoxypyridazin-3-(2H)-one 
• 67-56-1 methanol 
• 932-22-9 4,5-dichloro-2H-pyridazin-3-one 
• 74-88-4 methyl iodide 
• 933-76-6 4,5-dichloro-2-methyl-3(2H)-pyridazinone 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 25236-64-0 2,2,2-trifluoroethyl methanesulfonate 
• 6226-25-1 2,2,2-trifluoroethyl trifluoromethanesulphonate 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 214556-13-5 4-(5-Chloro-1-methyl-6-oxo-1,6-dihydro-pyridazin-4-yloxy)-benzonitrile 
• 214556-11-3 4-Chloro-5-(4-methoxy-phenoxy)-2-methyl-2H-pyridazin-3-one 
• 124-41-4 sodium methylate 

Downstream Products

• 476172-03-9 2-(5-methoxy-2-methyl-3-oxo-2,3-dihydropyridazin-4-yl)benzaldehyde 
• 863226-76-0 (S)-2-(2,6-Dichloro-benzoylamino)-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid 
• 862854-58-8 (S)-2-amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid 
• 929190-87-4 5-hydrazino-2-methyl-4-phenylpyridazin-3(2H)-one 
• 407577-73-5 4-chloro-2-methyl-5-phenylethynyl-pyridazin-3(2H)-one 
• 13563-36-5 2-methyl-4-amino-3(2H)-pyridazinone 
• 862854-59-9 (S)-2-amino-3-[4-(5-methoxy-2-methyl-3-oxo-2,3-dihydro-pyridazin-4-yl)-phenyl]-propionic acid trifluoroacetic acid salt 
• 1262422-95-6 5-[4-(3-chloro-phenylethynyl)-2-methyl-imidazol-1-yl]-2-methyl-2H-pyridazin-3-one 
• 14628-34-3 5-chloro-2-methyl-3(2H)-pyridazinone 

Relevant articles and documents

SULFONAMIDE DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF

PROBLEM TO BE SOLVED: To provide novel compounds having excellent α4 integrin inhibitory action. SOLUTION: The invention relates to sulfonamide derivatives represented by the general formula (I) in the figure, or pharmaceutically acceptable salts thereof, or prodrugs thereof. (In the formula, a, b, c, d, D, E, R11, B, e, f, g, h and W are as defined herein.) SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

IMIDAZOLES

The present invention relates to imidazole derivatives of the general formula wherein R1, R2, R3, and R4 are as defined in the specification and to pharmaceutically acceptable salts thereof. Compounds of formula I are metabotropic glutamate receptor antagonists. They can be used in the treatment or prevention of mGluR5 receptor mediated disorders.

Methyl carbonium ion migration during the reaction of 4-chloro-5-methoxyl- 3(2H)-pyridazinone with trifluoroethylation agents

To synthesize 4-chloro-5-methoxy-2-(β-trifluoroethyl)-3(2H)- pyridazinone (4), the reactions of 4-chloro-5-methoxy-3(2H)-pyridazinone (5) with RCH2CF3 (R = I, TsO, MsO, TfO) in different solvents were studied. It was found that methyl group migration took place during this reaction. An oxonium salt 9 was suggested as the active intermediate for the formation of the byproduct 4-chloro-5-methoxy-2-methyl-3(2H)-pyridazinone (7) and4-chloro-2-methyl-5-(β-trifluoroethoxy)-3(2)-pyridazinone(8).