146292-92-4

Basic information

• Product Name: 6-(ALLYLOXYCARBONYLAMINO)-1-HEXANOL
• Synonyms: 6-(ALLYLOXYCARBONYLAMINO)-1-HEXANOL;ALLYL N-(6-HYDROXYHEXYL)CARBAMATE;6-(ALLYLOXYCARBONYLAMINO)-1-HEXANOL PURUM 98%;6-(AllyloxycarbonylaMino)-1-haxanol
• CAS NO: 146292-92-4
• Molecular Formula: C₁₀H₁₉NO₃
• Molecular Weight: 201.26
• Product Categories: Amino Alcohols;Bifunctional Crosslinkers;Building Blocks;Chemical Biology;Chemical Synthesis;Linkers;Organic Building Blocks;Oxygen Compounds;Peptide Chemistry
• Mol File: 146292-92-4.mol
• Article Data: 1

Chemical Properties

• Melting Point: 46-49 °C
• Boiling Point: 328.8°C at 760 mmHg
• Flash Point: 152.7°C
• Appearance: /
• Density: 1.013g/cm³
• Vapor Pressure: 1.37E-05mmHg at 25°C
• Refractive Index: 1.466
• CAS DataBase Reference: 6-(ALLYLOXYCARBONYLAMINO)-1-HEXANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(ALLYLOXYCARBONYLAMINO)-1-HEXANOL(146292-92-4)
• EPA Substance Registry System: 6-(ALLYLOXYCARBONYLAMINO)-1-HEXANOL(146292-92-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 146292-92-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H19NO3/c1-2-9-14-10(13)11-7-5-3-4-6-8-12/h2,12H,1,3-9H2,(H,11,13)

Upstream product

• 4048-33-3 6-amino-1-hexanol 
• 2937-50-0 Allyl chloroformate 

Downstream Products

• 1639888-00-8 C₂₈H₄₄N₄O₁₀S 
• 1173156-20-1 2-({2-[({N-[6-((2R)-2-amino-4-phenylbutanoylaminooxy)hexyl]carbamoyl}methyl){2-[bis(carboxymethyl)amino]ethyl}amino]ethyl}(carboxymethyl)amino)acetic acid trifluoroacetic acid salt 
• 1173158-50-3 C₅₁H₈₈N₆O₁₃ 
• 1173158-48-9 (2R)-N-(6-aminohexyloxy)-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide trifluoroacetic acid salt 
• 1173156-12-1 2-({2-[({N-[6-((2R)-2-amino-3-cyclohexylpropanoylaminooxy)hexyl]carbamoyl}methyl){2-[bis(carboxymethyl)amino]ethyl}amino]ethyl}(carboxymethyl)amino)acetic acid trifluoroacetic acid salt 
• 1173158-23-0 C₅₀H₉₂N₆O₁₃ 
• 1173158-19-4 (2R)-N-(6-aminohexyloxy)-2-[(tert-butoxy)carbonylamino]-3-cyclohexylpropanamide trifluoroacetic acid salt 

Relevant articles and documents

'Clickable' 2,5-diketopiperazines as scaffolds for ligation of biomolecules: Their use in Aβ inhibitor assembly

The synthesis of 1,3,6-trisubstituted-2,5-diketopiperazine scaffolds bearing up to three 'clickable' sites for further oxime bond or alkyne-azide cycloaddition ligations is described. The orthogonally Boc/Alloc protected DKP precursors prepared from l-lysine residues and an aminohexyl arm are efficiently prepared on a gram scale by sequentially using Fukuyama-Mitsunobu alkylation, dipeptide coupling and diketopiperazine ring formation as key steps. These scaffolds, with their glyoxylyl, aminooxy, alkynyl or azido functions, are ready-to-use platforms for biomolecular assembly. Their potentiality in this field was proved through the chemoselective ligation of Aβ-binding motifs, the KLVFFA peptide and the curcumin molecule. The inhibitory effect of these conjugates on Aβ amyloid fibril formation is reported using thioflavin T fluorescence assays and AFM observation. This journal is the Partner Organisations 2014.