146298-30-8

Basic information

• Product Name: 4'-chloro-3-nitrobiphenyl-4-ol
• Synonyms: 4'-chloro-3-nitrobiphenyl-4-ol
• CAS NO: 146298-30-8
• Molecular Weight: 249.653
• Mol File: 146298-30-8.mol

Chemical Properties

• CAS DataBase Reference: 4'-chloro-3-nitrobiphenyl-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-chloro-3-nitrobiphenyl-4-ol(146298-30-8)
• EPA Substance Registry System: 4'-chloro-3-nitrobiphenyl-4-ol(146298-30-8)

Safety Data

• Hazardous Substances Data: 146298-30-8(Hazardous Substances Data)

Upstream product

• 28034-99-3 4'-Chloro-4-biphenylol 

Downstream Products

• 146298-46-6 5-Amino-4'-chloro-3-piperidin-1-ylmethyl-biphenyl-4-ol 

Relevant articles and documents

Potential Antimalarials. XVI 4'-Chloro-3-amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-Bromo(and 3'-trifluoromethyl)-3-(substituted amino)methyl-5-(7''-trifluoromethylquinolin-4''-yl)aminobiphenyl-2-ols

Twenty-four mono-Mannich bases of the general formulae 4'-chloro-3-amino-5-(substituted amino)methylbiphenyl-4-ols and 4'-bromo(and 3'-trifluoromethyl)-3-(substituted amino)methyl-5-(7''-trifluoromethylquinolin-4''-yl)aminobiphenyl-2-ols have been prepared by condensation of the 4-chloro heterocycle with 5-amino-3-(N-substituted amino)methyl-4'-chlorobiphenyl-4-ols or 5-amino-3-(N-substituted amino)methyl-4'-bromo(or 3'-trifluoromethyl)biphenyl-2-ols.The antimalarial activity of these products in in vitro tests against Plasmodium falciparum reveals many with IC50 values of 50-100 nM (chloroguine 20-40 nM).The biphenyl-2-ols were more active than comparable biphenyl-4-ols.