146308-18-1

Basic information

• Product Name: N-(1,3-benzodioxol-5-yl)-4-methylbenzenesulfonamide
• Synonyms: N-(1,3-benzodioxol-5-yl)-4-methylbenzenesulfonamide
• CAS NO: 146308-18-1
• Molecular Formula: C14H13NO4S
• Molecular Weight: 291.32232
• Mol File: 146308-18-1.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(1,3-benzodioxol-5-yl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1,3-benzodioxol-5-yl)-4-methylbenzenesulfonamide(146308-18-1)
• EPA Substance Registry System: N-(1,3-benzodioxol-5-yl)-4-methylbenzenesulfonamide(146308-18-1)

Safety Data

• Hazardous Substances Data: 146308-18-1(Hazardous Substances Data)

Upstream product

• 127-65-1 chloroamine-T 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 
• 14268-66-7 benzo[1,3]dioxolo-5-ylamine 
• 98-59-9 p-toluenesulfonyl chloride 

Relevant articles and documents

Synthesis of N -Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature

A copper-catalyzed Chan-Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N -arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups. In this process, it is believed that chloramine-T serves as an electrophile.

A Gold Carbene Manifold to Prepare Fused γ-Lactams by Oxidative Cyclisation of Ynamides

Gold-catalysed oxidative cyclisation reactions of ynamides offer great promise in γ-lactam synthesis but are limited by preferential over-oxidation to form α-keto imides. Evaluating the factors that might limit N-cyclisation pathways led to effective gold-catalysed conditions that allow access to different fused γ-lactams on changing the ynamide N-substituent and accommodate previously incompatible substitution patterns. New and efficient methods for the synthesis of functionalised 3-aryl indoles and cyclohepta[c]pyrrol-1-one derivatives are presented. These conditions illustrate the complementarity of gold catalysis to other metals.

Palladium-Catalyzed Regioselective Synthesis of 3-Arylindoles from N-Ts-Anilines and Styrenes

A Pd-catalyzed intermolecular oxidative annulation between N-Ts-anilines and styrenes was developed. This method offers a straightforward and robust approach to a wide range of 3-arylindoles using readily available starting materials with good functional-group tolerance and high regioselectivity and efficiency. Further elaboration of the products obtained from this process provided access to highly functionalized and structurally diverse indoles, for example, 3-(indol-3-yl)carbazoles, 1,9-dihydropyrrolo-[2,3-b]carbazoles, and 3′-aryl-3,5′-biindoles.