146337-39-5

Usage

Uses

Used in Pharmaceutical Industry:
1-Piperidinecarboxylic acid, 4-hydroxy-2,6-dimethyl-, 1,1-dimethylethyl ester, (2R,6R)-relis used as a second-generation antihistamine for the treatment of allergic rhinitis and chronic idiopathic urticaria. It works by blocking the action of histamine, reducing the symptoms of allergies.
Used in Medication Formulation:
Terfenadine is used as an active ingredient in tablet form for the management of allergic symptoms. It is usually taken once a day to provide relief from allergy-induced discomfort.
Note: Due to the potential adverse effects of terfenadine when taken with certain medications, it has been withdrawn from the market in many countries. Therefore, its use in pharmaceutical applications may be limited or restricted depending on the regulatory guidelines in specific regions.

Upstream product

• 34619-03-9 tert-butyldicarbonate 
• 1005397-64-7 tert-butyl-cis-2,6-dimethyl-4-oxopiperidine-1-carboxylate 
• 126503-27-3 trans-N-Boc-7,9-dimethyl-1,4-dioxa-8-azaspiro<4.5>decane 
• 126503-08-0 N-Boc-7-methyl-1,4-dioxa-8-azaspiro<4.5>decane 
• 184368-70-5 (2SR,6SR)-tert-butyl 2,6-dimethyl-4-oxopiperidine-1-carboxylate 

Relevant academic research and scientific papers

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

SPIRO[CYCLOBUTANE-1,3'-INDOLIN]-2'-ONE DERIVATIVES AS BROMODOMAIN INHIBITORS

The present invention provides novel spiro[cyclobutane-1,3'-indolin]-2'- derivatives of formula (I) in which Cy R1, R2, R4, L and 'm' are have the meaning given in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful as bromodomain inhibitors in the treatment or prevention of diseases or disorders where bromodomain inhibition is desired.

α-Lithioamine Synthetic Equivalents: Synthesis of Diastereoisomers from Boc Derivatives of Cyclic Amines

Sequences of α'-lithiations and electrophilic substitutions of Boc-pyrrolidines, Boc-piperidines, and Boc-hexahydroazepines that provide compounds which are substituted adjacent to nitrigen are reported, and the pathways of the reactions are discussed.By this methodology monosubstituted 2 and disubstituted 2,4, 2,6, and 2,5 Boc-piperidines are obtained as single or separable diastereoisomers consistent with equatorial lithiations and retentive electrophilic substitution in chair conformations.Both cis and trans 2,6-disubstituted diastereoisomers can be prepared, and control of diastereoselectivity is demonstrated by syntheses of solenopsin A, a 2,6-trans-disubstituted piperidine, and of Boc-dihydropinidine, a 2,6-cis-disubstituted piperidine.In the case of 3-methoxy-Boc-piperidine elimination of methoxide occurs upon lithiation, and with cis-2,4-disubstituted Boc-piperidines the electrophile is introduced with trans stereochemistry at C-6.These reactions are suggested to involve twist boat conformations consistent with an X-ray crystal structure of 2-methyl-6-(trimethylstannyl)-4-phenyl-N-Boc-piperidine.Boc-pyrrolidine lithiates more rapidly than Boc-piperidine, provides 2-substituted products with electrophiles, and on further lithiation-substitution gives 2,5-cis- and -trans substituted products.Boc-perhydroazepine provides 2-substituted products by the sequence and on further lithiation-substitution gives 2,7-trans-disubstituted products.