146341-49-3Relevant academic research and scientific papers
9-aminoacridine derivatives possessing psychotropic, antiamnestic and lipid-regulative activity
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, (2008/06/13)
"Derivatives of 9-aminoacridine characterized by psychothropic, antiamnestic and lipid-regulating activities". New chemical compounds derived of 9-aminoacridine with a general formula are presented: STR1 where R=H or CH3 R1 =H, CHsu
DERIVATIVES OF 9-AMINOACRIDINE HAVING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID REGULATING PROPERTIES
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, (2008/06/13)
New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH3; R1 = H, CH3, Br; R2 = H, CH3; R3 = alkyl-C1-C5, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH2; X + Y = CH = CH; and their salts with organic and non-organic acids. The desired compounds are obtained by interaction of substituted nitriles of antranyl acid with dimedone with subsequent cyclization of intermediate enaminonitriles into corresponding ketones of 9-aminoacridine after the reduction of which and of their derivatives alkylated or aralkylated on the 9-amino group, the corresponding alcohols are obtained, after hydration of which 9-amino-3,4-dihydroacridines are obtained. When experimented on animals, the said derivatives of 9-aminoacridine have shown psychotropic, antiamnestic and lipid regulating properties, as well as a lower toxicity in comparison with known preparations.
