1463484-39-0

Basic information

• Product Name: benzyl3a,4-dihydro-3H-pyrrolo[3,4-c]isoxazole-5(6H)-carboxylate
• Synonyms: benzyl3a,4-dihydro-3H-pyrrolo[3,4-c]isoxazole-5(6H)-carboxylate;EOS-60741;Benzyl 3A,4-Dihydro-3H-Pyrrolo[3,4-C]Isoxazole-5(6H)-Carboxylate(WXC01792)
• CAS NO: 1463484-39-0
• Molecular Formula: C₁₃H₁₄N₂O₃
• Molecular Weight: 245.25392
• Mol File: 1463484-39-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzyl3a,4-dihydro-3H-pyrrolo[3,4-c]isoxazole-5(6H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl3a,4-dihydro-3H-pyrrolo[3,4-c]isoxazole-5(6H)-carboxylate(1463484-39-0)
• EPA Substance Registry System: benzyl3a,4-dihydro-3H-pyrrolo[3,4-c]isoxazole-5(6H)-carboxylate(1463484-39-0)

Safety Data

• Hazardous Substances Data: 1463484-39-0(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 569682-60-6 benzyl N-(2,2-dimethoxyethyl)-N-(prop-2-en-1-yl)carbamate 
• 114790-39-5 benzyl N-(2,2-dimethoxyethyl)carbamate 
• 370880-75-4 benzyl N-(2-oxoethyl)-N-(prop-2-en-1-yl)carbamate 
• 370880-76-5 benzyl N-[2-(hydroxyimino)ethyl]-N-(prop-2-en-1-yl)carbamate 

Downstream Products

• 252770-09-5 benzyl (cis)-3-amino-4-(hydroxymethyl)-1-pyrrolidinecarboxylate 
• 1463484-71-0 benzyl 3-amino-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate 
• 1463484-74-3 benzyl 3-amino-4-(hydroxymethyl)-3-(2-thienyl)pyrrolidine-1-carboxylate 
• 1463486-24-9 benzyl (4aR,7aR)-2-benzamido-7a-(2-thienyl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazine-6-carboxylate 
• 1463485-06-4 benzyl (4aR,7aR)-2-(benzoylamino)-7a-(5-bromothiophen-2-yl)-4a,5,7,7a-tetrahydropyrrolo[3,4-d][1,3]thiazine-6(4H)-carboxylate 
• 1463485-07-5 benzyl (4aR,7aR)-2-(benzoylamino)-7a-(5-cyanothiophen-2-yl)-4a,5,7,7a-tetrahydropyrrolo[3,4-d][1,3]thiazine-6(4H)-carboxylate 
• 1463485-20-2 N-[(4aR,7aR)-7a-(5-cyanothiophen-2-yl)-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 
• 1463485-21-3 N-[(4aR,7aR)-7a-(2-thienyl)-4a,5,6,7-tetrahydro-4H-pyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 
• 1463485-30-4 N-{(4aR,7aR)-7a-(5-cyanothiophen-2-yl)-6-[5-fluoro-4-(2-hydroxypropan-2-yl)pyrimidin-2-yl]-4,4a,5,6,7,7a-hexahydropyrrolo[3,4-d][1,3]thiazin-2-yl}benzamide 
• 1463485-31-5 N-[(4aR,7aR)-6-(5-fluoropyrimidin-2-yl)-7a-(2-thienyl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-2-yl]benzamide 
• 1463484-79-8 benzyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-(2-thienyl)pyrrolidine-1-carboxylate 
• 1463484-45-8 benzyl 6a-(2-trimethylsilylthiazol-5-yl)-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c]isoxazole-5-carboxylate 
• 1463484-42-5 benzyl 6a-phenyl-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c]isoxazole-5-carboxylate 
• 1463484-43-6 benzyl 6a-(2-thienyl)-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c]isoxazole-5-carboxylate 

Relevant articles and documents

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The beta-site APP cleaving enzyme 1, known as BACE1, has been a widely pursued Alzheimer's disease drug target owing to its critical role in the production of amyloid-beta. We have previously reported the clinical development of LY2811376 and LY2886721. L

TOSYLATE SALT OF N-[3-[(4AR,7AS)-2-AMINO-6-(5-FLUOROPYRIMIDIN-2-YL)-4,4A,5,7-TETRAHYDROPYRROLO[3,4-D][1,3]THIAZIN-7A-YL]-4-FLUORO-PHENYL]-5-METHOXY-PYRAZINE-2-CARBOXAMIDE

The present invention provides a tosylate salt of N-[3-[(4aR,7aS)-2-amino-6-(5- fluoropyrimidin-2-yl)-4,4a,5,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a-yl]-4-fluoro- phenyl]-5-methoxy-pyrazine-2-carboxamide.

TETRAHYDROPYRROLOTHIAZINE COMPOUNDS

The present invention provides compounds of Formula I: wherein A is selected from the group consisting of; R1 is H or F; R2 is H, —CH2OH, C1-C3 alkyl, R3 is H, F, or CN; R4 is H, F; or CN; and R5 is H, —CH3, or —OCH3; or a pharmaceutically acceptable salt thereof.