1463535-67-2Relevant academic research and scientific papers
A one-pot three-component domino protocol for the synthesis of penta-substituted 4H-pyrans
Sivakumar, Sathiyamoorthi,Kanchithalaivan, Selvaraj,Kumar, Raju Ranjith
, p. 13357 - 13364 (2013/09/02)
A library of novel 2-(1H-indol-3-yl)-6-(methylamino)-5-nitro-4-aryl-4H- pyran-3-carbonitriles and 6-(methylamino)-4-(aryl)-5-nitro-2-phenyl-4H-pyran-3- carbonitriles were synthesized in excellent yields via domino one-pot three-component reactions of 3-(1H-indol-3-yl)-3-oxopropanenitrile or benzoylacetonitrile, aromatic aldehydes and (E)-N-methyl-1-(methylthio)-2- nitroethenamine respectively. This reaction presumably occurs via domino Knoevenagel condensation-Michael addition-intramolecular O-cyclization sequence of reactions. The significant advantages of this reaction include one-pot process, simple work-up procedure, excellent yields and no column chromatographic purification.
