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[(2E,4R)-4-amino-5-ethoxy-2-methyl-5-oxopent-2-en-1-yl]phosphonic acid, also known as AMEP, is a synthetic compound with potent anti-cancer and anti-osteoporotic properties. It acts as an inhibitor of cell proliferation and inducer of apoptosis in various cancer cell lines by modulating the expression of anti-apoptotic and pro-apoptotic proteins. Furthermore, AMEP demonstrates potential in treating osteoporosis by inhibiting bone resorption. Its mechanism of action involves inhibiting farnesyl pyrophosphate synthase, a key enzyme in the mevalonate pathway responsible for cholesterol and isoprenoid compound biosynthesis.

146388-56-9

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146388-56-9 Usage

Uses

Used in Pharmaceutical Industry:
AMEP is used as an anti-cancer agent for its ability to induce apoptosis and inhibit cell proliferation in a variety of cancer cell lines. It modulates oncological signaling pathways, leading to cell death and potentially offering a therapeutic option for cancer treatment.
Used in Orthopedic Applications:
AMEP is used as an anti-osteoporotic agent due to its potential to inhibit bone resorption, making it a promising candidate for the treatment of osteoporosis and related bone disorders.
Used in Drug Development:
AMEP's mechanism of action, targeting farnesyl pyrophosphate synthase, positions it as a potential lead compound in the development of new drugs for cancer and osteoporosis treatment. Further research is necessary to fully understand its potential applications and optimize its therapeutic efficacy.

Check Digit Verification of cas no

The CAS Registry Mumber 146388-56-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,3,8 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 146388-56:
(8*1)+(7*4)+(6*6)+(5*3)+(4*8)+(3*8)+(2*5)+(1*6)=159
159 % 10 = 9
So 146388-56-9 is a valid CAS Registry Number.

146388-56-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [(E,4R)-4-amino-5-ethoxy-2-methyl-5-oxopent-2-enyl]phosphonic acid

1.2 Other means of identification

Product number -
Other names Tocris-1409

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:146388-56-9 SDS

146388-56-9Upstream product

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