146409-33-8

Basic information

• Product Name: beta catenin
• Synonyms: beta catenin;id:ibd2058;wu:fb73e10;Catenin β, GST tagged human;FLJ25606;catenin (cadherin-associated protein) β 1;catenin β;CATNB
• CAS NO: 146409-33-8
• Molecular Weight: 0
• Mol File: 146409-33-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: beta catenin(CAS DataBase Reference)
• NIST Chemistry Reference: beta catenin(146409-33-8)
• EPA Substance Registry System: beta catenin(146409-33-8)

Safety Data

• WGK Germany: 1
• Hazardous Substances Data: 146409-33-8(Hazardous Substances Data)

Usage

Uses

Catenin β, GST tagged human has been used: as a component of protein kinase buffer for in vitro kinase assay in in vitro?citrullination assay to characterize β-catenin citrullination to perform differentiation factor screening

General Description

β-catenins are cytoplasmic proteins that are ubiquitously expressed. These proteins associate with E-cadherin at cellular junctions. CTNNB1 (catenin β-1) belongs to the armadillo family of proteins. This protein possesses a 130 amino acid N-terminal domain, 12 imperfect repeats of 42 amino acids termed arm repeats and a 100 amino acid C-terminal domain. The gene encoding β-catenin is localized on human chromosome 3p22.1.

Biochem/physiol Actions

β-catenin interacts with T-cell factor and lymphoid enhancer-binding factor (TCF and LEF) transcription factors and is an essential member of the Wingless-Wnt signal transduction pathway. The adenomatous polyposis coli (APC) tumor-suppressor protein, together with Axin and glycogen synthase kinase 3 β (GSK3β), form a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of βcatenin by the proteasome. APC and the Siah-1 E3 ubiquitin-protein ligase-1 mediate a novel β-catenin degradation pathway linking p53 activation to cell cycle control. Activating mutations in the human β-catenin gene have been found in human colon cancer and melanomas. The protein has a role in homeostasis and development.