1464154-80-0

Basic information

• Product Name: 2-chloro-4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid
• Synonyms: 2-chloro-4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid
• CAS NO: 1464154-80-0
• Molecular Weight: 374.786
• Mol File: 1464154-80-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid(1464154-80-0)
• EPA Substance Registry System: 2-chloro-4-(3-(4-cyanophenyl)imidazo[1,2-b]pyridazin-6-yl)benzoic acid(1464154-80-0)

Safety Data

• Hazardous Substances Data: 1464154-80-0(Hazardous Substances Data)

Upstream product

• 136496-72-5 2-chloro-4-(dihydroxyboryl)benzoic acid 
• 1082604-63-4 4-(6-chloroimidazo[1,2-b]pyridazin-3-yl)benzonitrile 
• 923595-49-7 6-chloro-3-iodo-imidazo[1,2-b]pyridazine 
• 126747-14-6 4-cyanophenylboronic acid 

Downstream Products

• 1464151-09-4 4-(6-(3-chloro-4-(4-methylpiperazine-1-carbonyl)phenyl)imidazo[1,2-b]pyridazin-3-yl)benzonitrile 

Relevant articles and documents

BICYCLIC HETEROCYCLIC DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF

The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.