146426-35-9

Basic information

• Product Name: antibiotic APHE 1
• Synonyms: antibiotic APHE 1
• CAS NO: 146426-35-9
• Molecular Formula: C13H12N2O
• Molecular Weight: 212.24718
• Mol File: 146426-35-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 412.6°Cat760mmHg
• Flash Point: 209.1°C
• Appearance: /
• Density: 1.206g/cm³
• Vapor Pressure: 1.23E-06mmHg at 25°C
• Refractive Index: 1.635
• CAS DataBase Reference: antibiotic APHE 1(CAS DataBase Reference)
• NIST Chemistry Reference: antibiotic APHE 1(146426-35-9)
• EPA Substance Registry System: antibiotic APHE 1(146426-35-9)

Safety Data

• Hazardous Substances Data: 146426-35-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H12N2O/c1-2-13-15-8-12(16-13)10-7-14-11-6-4-3-5-9(10)11/h3-8,14H,2H2,1H3

Upstream product

• 73053-92-6 N-<2-oxo-2-(1H-indol-3-yl)ethyl>propionamide 
• 7269-72-9 3-indolylglyoxal 
• 2835-81-6 2-aminobutanoic acid 
• 703-80-0 3-acetylindole 
• 57642-05-4 2-iodo-1-(1H-indol-3-yl)ethanone 
• 65601-06-1 N-<2-(1H-indol-3-yl)ethyl>propanamide 
• 343-94-2 tryptamine hydochloride 
• 120191-50-6 5-(1H-indol-3-yl)oxazole 
• 776-41-0 indole-3-carboxylic acid ethyl ester 
• 124687-95-2 1-(3-(1-tert-butoxycarbonyl)indolyl)-2-diazo-1-ethanone 
• 123-62-6 propionic acid anhydride 

Relevant articles and documents

Natural product Pimprinine derivative as well as preparation method and application thereof

The invention discloses a Pimprinine derivative as shown in a formula III in the description. The invention also discloses a preparation method of the Pimprinine derivative, and a series of Pimprinine derivatives are synthesized by taking Pimprinine as a lead, combining the structural characteristics of Pimprinine, taking cheap and easily available indole as a raw material, modifying and transforming different sites of a framework structure of the indole and introducing different substituent groups. The Pimprinine derivative disclosed by the invention has good bactericidal activity, shows efficient and/or broad-spectrum bactericidal activity, and can be applied to crop diseases caused by fungi, bacteria and viruses.

A 5 - (3 - indolyl) - oxazole compound of preparation method

The invention discloses a preparation method of a 5-(3-indolyl)-oxazole compound with a structure as shown in the formula (I). The method comprises the following step: in the presence of iodine and dimethyl sulfoxide, a compound with a structure as shown in the formula (II) and a compound with a structure as shown in the formula (III) undergo a contact reaction. Raw materials used in the preparation method are cheap and easily available. The preparation method is simple and the preparation step is short. In addition, the contact reaction can be carried out by a one kettle way during synthetic operation. Yield is high and can reach 84%. The preparation method provided by the invention is especially suitable for industrial production.

Synthesis of 5-(3-indolyl)oxazole natural products. Structure revision of Almazole D

The synthesis and utility of β-oxotryptamine and β-oxytryptophan ester synthons provide a convenient entry to 5-(3-indolyl)oxazole natural products leading to a structure revision of almazole D.