146426-40-6 Usage
Uses
Different sources of media describe the Uses of 146426-40-6 differently. You can refer to the following data:
1. Antineoplastic (cyclin-dependent kinase
inhibitor)[Note—The trivial name, flavopiridol, has
appeared in literature].
2. Flavopiridol is a synthetic flavonoid derivative, potent inhibitor of CDKs. Inhibitor of CDK9 as a postexposure drug target for adenoviruses.
Anticancer Research
It is a synthetic derivative of rohitukine plant alkaloid which is obtained fromDysoxylum binectariferum, which is active against leukemia, lymphomas and solidtumors (Shoeb 2006).
Check Digit Verification of cas no
The CAS Registry Mumber 146426-40-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,4,2 and 6 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 146426-40:
(8*1)+(7*4)+(6*6)+(5*4)+(4*2)+(3*6)+(2*4)+(1*0)=126
126 % 10 = 6
So 146426-40-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24,26-27H,6-7,10H2,1H3/t12-,17+/m1/s1
146426-40-6Relevant articles and documents
COMBINATION THERAPIES FOR TREATMENT OF MYELODYSPLASTIC SYNDROME
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Paragraph 00626-00627; 00631, (2021/06/11)
The present invention relates to methods for treatment of myelodysplastic syndrome (MDS) by administration of a hypomethylating agent (HMA), such as azacitidine or decitabine, or a prodrug of either of the foregoing, or a pharmaceutically acceptable salt of any of the foregoing, and alvocidib, or a prodrug thereof, or a pharmaceutically acceptable salt of the foregoing.
METHODS FOR TREATING CASTRATION-RESISTANT AND CASTRATION- SENSITIVE PROSTATE CANCER
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Page/Page column 86-87, (2020/07/05)
Methods of treating castration-resistant and castrati on- sensitive prostate cancer using a compound having the following structure (I): or a pharmaceutically acceptable salt or zwitterionic form thereof, are provided.