146427-85-2Relevant academic research and scientific papers
Synthesis and anti-inflammatory activity of N-(aza)arylcarboxamides derived from Trolox
Moulin, Claudie,Duflos, Muriel,Le Baut, Guillaume,Grimaud, Nicole,Renard, Pierre,Caignard, Daniel-Henri
, p. 321 - 329 (2007/10/03)
A series of 6-(aza)arylmethoxychroman-2-carboxamides 22-38, derived from Trolox or 6-hydroxy-2,5,7,8-tetra-methylchroman-2-carboxylic acid, was prepared using two strategies, i.e. phenol blockade was carried out before or after amidification. These compounds were evaluated against peripheral inflammation by a carrageenin-induced foot-pad edema test. A permanent blockade of the phenol function by arylmethoxy groupings, in particular by the quinolylmethoxy moiety, was generally detrimental to activity; only the 6-benzyloxy and quinolylmethoxy derivatives 22 and 31 exhibited significant inhibition (58.3 and 97.1%) after oral administration of 0.4 mrnol kg-1. Among their 6-acetoxy or 6-hydroxy precursors 12-21. evaluated at 0.4 and 0.1 mmol kg-1, the N-(4-pyridyl) chromancarboxamides 15 and 20 exerted the highest inhibitory activity. Their ID50 were 14.7 ± 5.5 mg kg-1 and 14.7 ± 4.5 mg kg-1, respectively. Elsevier, Paris.
