146446-11-9Relevant articles and documents
Synthetic Studies on Selective, Proapoptotic Isomalabaricane Triterpenoids Aided by Computational Techniques
Boyko, Yaroslav D.,Huck, Christopher J.,Ning, Shang,Shved, Alexander S.,Yang, Cheng,Chu, Tiffany,Tonogai, Emily J.,Hergenrother, Paul J.,Sarlah, David
, p. 2138 - 2155 (2021)
The isomalabaricanes comprise a large family of marine triterpenoids with fascinating structures that have been shown to be selective and potent apoptosis inducers in certain cancer cell lines. In this article, we describe the successful total syntheses of the isomalabaricanes stelletin A, stelletin E, and rhabdastrellic acid A, as well as the development of a general strategy to access other natural products within this unique family. High-throughput experimentation and computational chemistry methods were used in this endeavor. A preliminary structure-activity relationship study of stelletin A revealed the trans-syn-trans core motif of the isomalabaricanes to be critical for their cytotoxic activity.
Gibepyrones: α-Pyrones from Gibberella fujikuroi
Barrero, Alejandro F.,Oltra, Juan E.,Herrador, Maria M.,Cabrera, Eduardo,Sanchez, Juan F.,et al.
, p. 141 - 150 (2007/10/02)
Six α-pyrones, called gibepyrones A-F, were identified in three different culture media of G. fujikuroi (IMI 58289).Their structures were determined using both spectroscopic techniques and chemical synthesis.Their antimicrobial activity has been screened.
