146452-36-0

Basic information

• Product Name: 2H-1,3,2-Oxazaphosphorin-2-amine,N-(2-bromoethyl)-3-(2-chloroethyl)tetrahydro-, 2-oxide
• Synonyms: Bromofosfamide; KM 135
• CAS NO: 146452-36-0
• Molecular Formula: C₇H₁₅BrClN₂O₂P
• Molecular Weight: 305.537
• Mol File: 146452-36-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 349.7°Cat760mmHg
• Flash Point: 165.3°C
• Density: 1.54g/cm³
• CAS DataBase Reference: 2H-1,3,2-Oxazaphosphorin-2-amine,N-(2-bromoethyl)-3-(2-chloroethyl)tetrahydro-, 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-1,3,2-Oxazaphosphorin-2-amine,N-(2-bromoethyl)-3-(2-chloroethyl)tetrahydro-, 2-oxide(146452-36-0)
• EPA Substance Registry System: 2H-1,3,2-Oxazaphosphorin-2-amine,N-(2-bromoethyl)-3-(2-chloroethyl)tetrahydro-, 2-oxide(146452-36-0)

Safety Data

• Hazardous Substances Data: 146452-36-0(Hazardous Substances Data)

Upstream product

• 3778-73-2 ilfosfamide 
• 72578-74-6 (S)-(-)-2-aziridino-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide 
• 72578-73-5 (R)-(+)-2-aziridino-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide 
• 84711-20-6 (+)-ifosfamide 
• 84711-20-6 (-)-iphosphamide 
• 29102-47-4 2-aziridino-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin 2-oxide 

Relevant articles and documents

Synthesis and Antitumor Activity of Analogues of Ifosfamide Modified in the N-(2-Chloroethyl) Group

A series of 3-(2-chloroethyl)-N-(2-X-ethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxides with various X substituents have been prepared by cyclization of racemic ifosfamide or its enantiomers with sodium hydride and subsequent treatment of intermed