146464-92-8

Basic information

• Product Name: 6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl-
• Synonyms: 6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl-;6-Pteridinepropanoic acid, 2,4-diaMino-a-(4-carboxyphenyl)-a-2-propynyl-;6-Pteridinepropanoic acid, 2,4-diaMino-α-(4-carboxyphenyl)-α-2-propyn-1-yl-;4-(2-Carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid;10-Propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid;2,4-Diamino-alpha-(4-carboxyphenyl)-alpha-2-propynyl-6-pteridinepropanoic acid
• CAS NO: 146464-92-8
• Molecular Formula: C₁₉H₁₆N₆O₄
• Molecular Weight: 392.36814
• Mol File: 146464-92-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 718.9±70.0 °C(Predicted)
• Appearance: /
• Density: 1.555±0.06 g/cm3(Predicted)
• PKA: 2.65±0.10(Predicted)
• CAS DataBase Reference: 6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl-(146464-92-8)
• EPA Substance Registry System: 6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl-(146464-92-8)

Safety Data

• Hazardous Substances Data: 146464-92-8(Hazardous Substances Data)

Usage

General Description

6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl- is a chemical compound with a complex structure and name. It is a pteridine derivative with a propynyl group and a carboxyphenyl group attached to the 2,4-diaminopropanoic acid core. 6-Pteridinepropanoic acid, 2,4-diamino-.alpha.-(4-carboxyphenyl)-.alpha.-2-propyn-1-yl- has potential relevance in the field of biochemistry and pharmaceuticals due to its structural complexity and potential biological activity. Further research and study of this compound may reveal its potential uses and applications in various fields, including medicine and industry.

Upstream product

• 501-89-3 4-(carboxymethyl)benzoic acid 
• 1548618-47-8 10-propargyl-10-carbomethoxy-4-deoxy-4-amino-10-deazapteroic acid methyl ester hydrobromide salt 
• 52853-40-4 6-bromomethyl-2,4-diaminopteridine hydrobromide 
• 52787-14-1 methyl 4-(2-methoxy-2-oxoethyl)benzoate 
• 146464-91-7 methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate 
• 146464-90-6 α-propargylhomoterephthalic acid dimethyl ester 

Downstream Products

• 146464-93-9 4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid 
• 146464-91-7 methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate 
• 1445586-44-6 potassium 10-propargyl-4-deoxy-4-amino-10-deazapteroate 
• 1445586-43-5 4-(3-((2,4-diaminopteridin-6-yl)methyl)-5-methylene-2-oxotetrahydrofuran-3-yl)benzoic acid 
• 1445586-50-4 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt 
• 1445586-53-7 lithium 10-propargyl-4-deoxy-4-amino-10-deazapteroate 
• 1320211-82-2 C₂₅H₂₇N₇O₅ 
• 1320211-79-7 C₂₅H₂₇N₇O₅ 
• 374777-77-2 10-propargyl-10-deazaaminopterin dimethyl ester 
• 146464-94-0 10-propargyl-10-deazaaminopterin diethyl ester 
• 146464-95-1 pralatrexate 
• 948552-65-6 C₂₃H₂₄N₆O₄ 

Relevant articles and documents

A suitable industrial production pula Qu Sha method for the preparation of

The invention relates to the field of pharmaceutical chemistry technology, and more specifically relates to an anticarcinogen 10-Propargyl-10-deazaaminopterin (Pralatrexate) and synthesis of an intermediate thereof. The invention has the advantages of simple operation, low contents of related impurities, easiness in purification of intermediate, thereby avoiding purification mode of column chromatography, and the invention can be applied to large scale production of Pralatrexate bulk drug as well as preparation and purification method of important intermediates.

IMPROVED PROCESS FOR THE PREPARATION OF PRALATREXATE

An improved process for the preparation of Pralatrexate which is less hazardous. The invention further relates to novel intermediates and process thereof useful for the preparation of Pralatrexate. The present invention also relates to a substantially pure Pralatrexate and a process for obtaining the same in high yield.

PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE

Processes for preparing and purifying Pralatrexate are described in the present application, as well as intermediates in these processes, and salts and solid state forms of the Pralatrexate intermediates.