1464776-39-3Relevant academic research and scientific papers
Cu-promoted oxidative trifluoromethylation of terminal alkynes with difluoromethylene phosphobetaine
Deng, Xiaoyun,Lin, Jinhong,Zheng, Jian,Xiao, Jichang
, p. 689 - 693 (2014/10/15)
Difluoromethylene phosphobetaine (Ph3P+CF 2CO2-, PDFA), a known difluorocarbene reagent, was found to be able to efficiently trifluoromethylate terminal alkynes in the presence of Cu(I) and potassium fluoride. The transformation proceeded smoothly to afford the corresponding trifluoromethylated acetylenes in moderate yields. A difluorocarbene precursor, difluoromethylene phosphobetaine (Ph 3P+CF2CO2-, PDFA) was found to be able to act as a trifluoromethylating reagent in the presence of fluoride. The oxidative trifluoromethylation of terminal alkynes with PDFA promoted by Cu(I) occurred smoothly to give the corresponding trifluoromethylated acetylenes in moderate yields. Copyright
Copper-mediated trifluoromethylation of terminal alkynes by S-(trifluoromethyl)diarylsulfonium salt
Wang, Xiaoping,Lin, Jinhong,Zhang, Chengpan,Xiao, Jichang,Zheng, Xing
, p. 915 - 920 (2013/08/23)
The copper-mediated trifluoromethylation of terminal alkynes with S-(trifluoromethyl)diarylsulfonium salt has been carefully investigated. The reactions proceeded smoothly to afford trifluoromethylated acetylenes in moderate to good yields. This approach is a convenient method to synthesize a variety of functional trifluoromethylated acetylenes. A convenient method for the trifluoromethylation of a variety of terminal alkynes with S-(trifluoromethyl)diarylsulfoniumtriflate in the presence of copper iodide was described. The reactions proceeded smoothly under mild condition to give the desired product in moderate to good yields. Copyright
