1464809-19-5Relevant academic research and scientific papers
Exo-Selective construction of spiro-[butyrolactone-pyrrolidine] via 1,3-dipolar cycloaddition of azomethine ylides with α-methylene-γ- butyrolactone catalyzed by Cu(I)/DTBM-BIPHEP
Li, Qing-Hua,Liu, Tang-Lin,Wei, Liang,Zhou, Xiang,Tao, Hai-Yan,Wang, Chun-Jiang
, p. 9642 - 9644 (2013)
An expedient access to optically active spiro-[butyrolactone-pyrrolidine] was successfully developed via an unprecedented Cu(i)-catalyzed exo-selective 1,3-DC of azomethine ylides with α-methylene-γ-butyrolactone, which exhibited high diastereoselectivity (>98:2), excellent enantioselectivity (96->99% ee) and a broad substrate scope under mild conditions. The Royal Society of Chemistry 2013.
