146501-49-7Relevant academic research and scientific papers
Synthetic study on an antitumor antibiotic rhizoxin using an enzymatic process on prochiral β-substituted glutarates
Kobayashi, Susumu,Nakada, Masahisa,Ohno, Masaji
, p. 159 - 162 (2007/10/02)
Enantio- and stereoselective synthesis of the right-half segment (1; C1-C9) of the macrolide antibiotic rhizoxin has been achieved by enzymatic approach.Characteristic features of the present synthesis are (i) enantioselective hydrol
Enantioselective Hydrolysis of Dialkyl 3-Monosubstituted Glutarates with Pig Liver Esterase: Structure-Optical Purity Relationships
Nakada, Masahisa,Kobayashi, Susumu,Ohno, Masaji,Iwasaki, Shigeo,Okuda, Shigenobu
, p. 3951 - 3954 (2007/10/02)
Dialkyl 3-monosubstituted glutarates are subjected to hydrolysis with pig liver esterase to afford the corresponding chiral half-esters.Synnthetically useful half-esters of higher optical purity are obtained from the prochiral substrates of more hydrophob
