1465044-58-9

Upstream product

• 1155371-80-4 (((4-isopropyl-1,3-phenylene)bis(oxy))bis(methylene))dibenzene 
• 1155371-78-0 2-(2,4-bis(benzyloxy)phenyl)propan-2-ol 
• 22877-01-6 2,4-bis(benzyloxy)acetophenone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 958888-27-2 5-isopropyl-2,4-dihydroxy benzaldehyde 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1465044-62-5 1-(5-isopropyl-2,4-bis((4-methoxybenzyl)oxy)phenyl)prop-2-en-1-one 
• 1465044-65-8 1-(5-isopropyl-2,4-bis((4-methoxybenzyl)oxy)phenyl)-4-(pyridin-3-yl)butane-1,4-dione 
• 1465044-67-0 4-(4-(2-(5-isopropyl-2,4-bis((4-methoxybenzyl)oxy)phenyl)-5-(pyridin-3-yl)-1H-pyrrol-1-yl)phenyl)morpholine 
• 1465044-47-6 4-isopropyl-6-(1-(4-morpholinophenyl)-5-(pyridin-3-yl)-1H-pyrrol-2-yl)benzene-1,3-diol 
• 1465044-60-3 1-(5-isopropyl-2,4-bis((4-methoxybenzyl)oxy)phenyl)prop-2-en-1-ol 

Relevant academic research and scientific papers

HEAT SHOCK PROTEIN 90 INHIBITORS

Substituted aromatic compounds of formula (I) shown below: (formula I) The definition of each variable in formula (I) appears in the Specification. Also disclosed is a pharmaceutical composition containing one of the substituted aromatic compounds. Further disclosed is a method of using one of these compounds for treating a medical condition associated with HSP90.

NOVEL TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY

The present invention relates to novel triazole Hsp90 inhibitors that possess significant inhibitory activity against Hsp90, which are suitable for the treatment of hyperproliferative diseases such as cancer, infections, immune disorders, inflammation, and CNS related disorders. Furthermore, pharmaceutical compositions, including combination products, are also provided in the present application. Further provided are methods of using the pharmaceutical compositions and/or combination products.