14653-77-1

Basic information

• Product Name: Amifostine Thiol Dihydrochloride
• Synonyms: Amifostine Thiol Dihydrochloride;2-[(3-Aminopropyl)amino]ethanethioldihydrochloride;Amifostine Thiol (50 mg) (2-[(3-aminopropyl)amino]ethanethiol, dihydrochloride);AMifostine Thiol;2-[(3-AMinopropyl)aMino]ethanethiol Hydrochloride;WR-1065 dihydrochloride;WR-1065 2HCl
• CAS NO: 14653-77-1
• Molecular Formula: C₅H₁₄N₂S*2ClH
• Molecular Weight: 134.24306
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 14653-77-1.mol
• Article Data: 0

Chemical Properties

• Melting Point: 184-186°C
• Boiling Point: 218.6 °C at 760 mmHg
• Flash Point: 86 °C
• Appearance: white to off-white/
• Density: 0.975 g/cm³
• Vapor Pressure: 0.124mmHg at 25°C
• Storage Temp.: Desiccate at -20°C
• Solubility: H2O: ≥20mg/mL
• Stability: Hygroscopic
• CAS DataBase Reference: Amifostine Thiol Dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Amifostine Thiol Dihydrochloride(14653-77-1)
• EPA Substance Registry System: Amifostine Thiol Dihydrochloride(14653-77-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39-41
• WGK Germany: 3
• Hazardous Substances Data: 14653-77-1(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

A metabolite of Amifostine.

Biochem/physiol Actions

WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy.

InChI:InChI=1/C5H14N2S.2ClH/c6-2-1-3-7-4-5-8;;/h7-8H,1-6H2;2*1H

Downstream Products

• 136884-66-7 N¹-[2-(2,8,9-Trithia-5-aza-1-sila-bicyclo[3.3.3]undec-1-ylsulfanyl)-ethyl]-propane-1,3-diamine; hydrochloride