1465326-80-0

Basic information

• Product Name: 4-Amino-3-fluoro-5-methylbenzonitrile
• Synonyms: 4-Amino-3-fluoro-5-methylbenzonitrile;4-AMINO-3-FLUORO-5-METHYLBENZONITRILE（WS201527）;Benzonitrile, 4-amino-3-fluoro-5-methyl-
• CAS NO: 1465326-80-0
• Molecular Formula: C8H7FN2
• Molecular Weight: 150.1529832
• Mol File: 1465326-80-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 285.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.20±0.1 g/cm3(Predicted)
• PKA: 0.18±0.10(Predicted)
• CAS DataBase Reference: 4-Amino-3-fluoro-5-methylbenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Amino-3-fluoro-5-methylbenzonitrile(1465326-80-0)
• EPA Substance Registry System: 4-Amino-3-fluoro-5-methylbenzonitrile(1465326-80-0)

Safety Data

• Hazardous Substances Data: 1465326-80-0(Hazardous Substances Data)

Usage

General Description

4-amino-3-fluoro-5-methylbenzonitrile is a chemical compound with the molecular formula C8H7FN2. It is a nitrile derivative of benzonitrile, with a 4-amino-3-fluoro-5-methyl substituent. 4-amino-3-fluoro-5-methylbenzonitrile is often used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals. It has potential applications in the manufacturing of drugs and pharmaceutical products. Additionally, it may also be utilized in research and development as a building block for the synthesis of other chemical compounds. Due to its specific chemical structure and properties, 4-amino-3-fluoro-5-methylbenzonitrile has potential industrial and scientific applications.

Upstream product

• 557-21-1 zinc(II) cyanide 
• 429683-46-5 4-bromo-2-fluoro-6-methylbenzeneamine 
• 443-89-0 2-fluoro-6-methylaniline 

Relevant articles and documents

ROR[gamma] inhibitors, preparation method thereof and application of the ROR[gamma] inhibitors in medicine

The present specification provides compounds of formula (I) shown in the specification: or a pharmaceutically acceptable salt thereof, a deuterated compound, a tautomer, a cis-trans-isomer, a mesomer, a raceme, an enantiomer, a diastereoisomer, or a mixtu

NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention discloses compounds according to Formula (I), wherein R1, R3, R4, R5, L1, and Cy are as defined herein. The present invention also provides compounds, methods for the production of said compounds of the invention, pharmaceutical compositions comprising the same and their use in allergic or inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6 and/or interferons. The present invention also methods for the prevention and/or treatment of the aforementioned diseases by administering a compound of the invention.

2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors

New non-nucleoside reverse transcriptase inhibitors (NNRTI), which are similar in structure to earlier described di(arylamino)pyrimidines but featuring a 2,6-di(arylamino)-3-fluoropyridine, 2,4-di(arylamino)-5-fluoropyrimidine, or 1,3-di(arylamino)-4-fluorobenzene moiety instead of a 2,4-disubstituted pyrimidine moiety, are reported. The short and practical synthesis of novel NNRTI relies on two sequential Pd-catalyzed aminations as the key steps. It is demonstrated through direct comparison with reference compounds that the presence of a fluorine atom increases the in vitro anti-HIV activity, both against the wild type virus and drug-resistant mutant strains.